najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2016-7-4-759-764najo-1357Research ArticleСтатьиSynthesis and characterization of neomycin functionalized chitosan stabilized silver nanoparticles and study its antimicrobial activitySynthesis and characterization of neomycin functionalized chitosan stabilized silver nanoparticles and study its antimicrobial activityPreethikaR. K.PreethikaR. K.

Department of Chemistry

Madurai–625009

Department of Chemistry

Madurai–625009

RamyaR.RamyaR.

Department of Inorganic Chemistry

Guindy Campus, Chennai–600025

Department of Inorganic Chemistry

Guindy Campus, Chennai–600025

GanesanM.GanesanM.

Department of Chemistry

Madurai–625009

Department of Chemistry

Madurai–625009

NagarajS.NagarajS.

CASBotany

Guindy Campus, Chennai–600025

CASBotany

Guindy Campus, Chennai–600025

PandianK.PandianK.

Department of Inorganic Chemistry

Guindy Campus, Chennai–600025

Department of Inorganic Chemistry

Guindy Campus, Chennai–600025

jeevapandian@yahoo.co.ukThiagarajar CollegeThiagarajar CollegeUniversity of MadrasUniversity of Madras20162208202574759764Copyright © Preethika R.K., Ramya R., Ganesan M., Nagaraj S., Pandian K., 20252025Preethika R.K., Ramya R., Ganesan M., Nagaraj S., Pandian K.Preethika R.K., Ramya R., Ganesan M., Nagaraj S., Pandian K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/1357

A simple green method was developed for the synthesis of silver nanoparticles in the presence of a neomycin-functionalized chitosan as stabilizing agent using a fresh lemon juice as green reducing agent. The stabilizing agent was synthesized based on the Schiff base formation reaction between the chitosan dialdehyde and neomycin antibiotic in 0.05 mM at pH 7.0. The combined form of neomycin antibiotic with chitosan can be used as stabilizing agent for silver nanoparticles (AgNPs) synthesized by a biogenic method using lemon juice as a green reducing agent. The neomycin functionalized chitosan stabilized AgNPs were characterized by various analytical techniques, including UV- Visible spectra studies, FTIR, XRD and SEM. The antimicrobial activity of these composite was tested against human pathogenic Gram-positive and Gram-negative bacteria. The synergetic effect of the neomycin functionalized chitosan protected silver nanoparticles was tested against various drug resistant microorganisms. These chitosan derivatives can be used in combination with an anti-bacterial agent to treat and inhibit a resistant bacterial infection or the growth of resistant bacterial infection.

A simple green method was developed for the synthesis of silver nanoparticles in the presence of a neomycin-functionalized chitosan as stabilizing agent using a fresh lemon juice as green reducing agent. The stabilizing agent was synthesized based on the Schiff base formation reaction between the chitosan dialdehyde and neomycin antibiotic in 0.05 mM at pH 7.0. The combined form of neomycin antibiotic with chitosan can be used as stabilizing agent for silver nanoparticles (AgNPs) synthesized by a biogenic method using lemon juice as a green reducing agent. The neomycin functionalized chitosan stabilized AgNPs were characterized by various analytical techniques, including UV- Visible spectra studies, FTIR, XRD and SEM. The antimicrobial activity of these composite was tested against human pathogenic Gram-positive and Gram-negative bacteria. The synergetic effect of the neomycin functionalized chitosan protected silver nanoparticles was tested against various drug resistant microorganisms. These chitosan derivatives can be used in combination with an anti-bacterial agent to treat and inhibit a resistant bacterial infection or the growth of resistant bacterial infection.

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The authors declare that there are no conflicts of interest present.