<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">najo</journal-id><journal-title-group><journal-title xml:lang="en">Nanosystems: Physics, Chemistry, Mathematics</journal-title><trans-title-group xml:lang="ru"><trans-title>Наносистемы: физика, химия, математика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-8054</issn><issn pub-type="epub">2305-7971</issn><publisher><publisher-name>Университет ИТМО</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">najo-1424</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Synthesis and modification of zinc oxide nanostructures for conductometric immunosensor development</article-title><trans-title-group xml:lang="ru"><trans-title>Синтез и модификация наноструктур оксида цинка для создания кондуктометрического иммуносенсора</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ширяев</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shiryaev</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Химический факультет</p><p>Москва</p></bio><bio xml:lang="en"><p>Chemistry Department</p><p>Moscow</p></bio><email xlink:type="simple">shiryaev.michael@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Химический факультет</p><p>Москва</p></bio><bio xml:lang="en"><p>Chemistry Department</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский Государственный Университет им. М. В. Ломоносова</institution></aff><aff xml:lang="en"><institution>M. V. Lomonosov Moscow State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>29</day><month>08</month><year>2025</year></pub-date><volume>4</volume><issue>1</issue><fpage>90</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Shiryaev M.A., Baranov A.N., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ширяев М.А., Баранов А.Н.</copyright-holder><copyright-holder xml:lang="en">Shiryaev M.A., Baranov A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nanojournal.ifmo.ru/jour/article/view/1424">https://nanojournal.ifmo.ru/jour/article/view/1424</self-uri><abstract><p>In present paper zinc oxide nanostructure synthesis and modification for bioanalytical applications are described. Properties of modified zinc oxide array have been studied, and original scheme for conductometric immunosensor has been proposed.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящей статье описан синтез и модификация наноструктур оксида цинка для биоаналитических применений. Были изучены свойства модифицированного массива наностержней оксида цинка, а также предложена оригинальная схема устройства для создания кондуктометрического иммуносенсора</p></trans-abstract><kwd-group xml:lang="ru"><kwd>оксид цинка</kwd><kwd>биосенсоры</kwd><kwd>наностержни</kwd><kwd>модификация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>zinc oxide</kwd><kwd>biosensors</kwd><kwd>nanorods</kwd><kwd>modification</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Clark L.C., Lyons C. Electrode Systems for Continuous Monitoring in Cardiovascular Surgery // Annals of the New York Academy of Sciences. — 1962. — V. 102, No. 1. — P. 29–45.</mixed-citation><mixed-citation xml:lang="en">Clark L.C., Lyons C. Electrode Systems for Continuous Monitoring in Cardiovascular Surgery // Annals of the New York Academy of Sciences. — 1962. — V. 102, No. 1. — P. 29–45.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao Z., Lei W., et al. ZnO-Based Amperometric Enzyme Biosensors // Sensors. — 2010. — V. 10, No. 2. — P. 1216–1231.</mixed-citation><mixed-citation xml:lang="en">Zhao Z., Lei W., et al. ZnO-Based Amperometric Enzyme Biosensors // Sensors. — 2010. — V. 10, No. 2. — P. 1216–1231.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Пономарева О.Н., Решетилов А.Н., Алферов В.А. Биосенсоры. Принципы функционирования и практическое применение. — Изд-во ТулГУ, Тула, 2007. — 255 с.</mixed-citation><mixed-citation xml:lang="en">Пономарева О.Н., Решетилов А.Н., Алферов В.А. Биосенсоры. Принципы функционирования и практическое применение. — Изд-во ТулГУ, Тула, 2007. — 255 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Negahdary M., Asadi A., et al. A Biosensor for Determination of H2O2 by Use of HRP Enzyme and Modified CPE With Zno Nps // International Journal of Electrochemical Science. — 2012. — V. 7, No. 6. — P. 5185–5194.</mixed-citation><mixed-citation xml:lang="en">Negahdary M., Asadi A., et al. A Biosensor for Determination of H2O2 by Use of HRP Enzyme and Modified CPE With Zno Nps // International Journal of Electrochemical Science. — 2012. — V. 7, No. 6. — P. 5185–5194.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ali S.M., Ibupoto Z.H., et al. Potentiometric Indirect Uric Acid Sensor Based on ZnO Nanoflakes and Immobilized Uricase // Sensors. — 2012. — V. 12, No. 3. — P. 2787–2797.</mixed-citation><mixed-citation xml:lang="en">Ali S.M., Ibupoto Z.H., et al. Potentiometric Indirect Uric Acid Sensor Based on ZnO Nanoflakes and Immobilized Uricase // Sensors. — 2012. — V. 12, No. 3. — P. 2787–2797.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gu B., Xu C., et al. ZnO quantum dot labeled immunosensor for carbohydrate antigen 19–9 // Biosensors &amp; Bioelectronics. — 2011. — V. 26, No. 5. — P. 2720–2723.</mixed-citation><mixed-citation xml:lang="en">Gu B., Xu C., et al. ZnO quantum dot labeled immunosensor for carbohydrate antigen 19–9 // Biosensors &amp; Bioelectronics. — 2011. — V. 26, No. 5. — P. 2720–2723.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Teng Y., Zhang X., et al. Optimized ferrocene-functionalized ZnO nanorods for signal amplification in electrochemical immunoassay of Escherichia coli // Biosensors &amp; Bioelectronics. — 2011. — V. 26, No. 12. — P. 4661–4666.</mixed-citation><mixed-citation xml:lang="en">Teng Y., Zhang X., et al. Optimized ferrocene-functionalized ZnO nanorods for signal amplification in electrochemical immunoassay of Escherichia coli // Biosensors &amp; Bioelectronics. — 2011. — V. 26, No. 12. — P. 4661–4666.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hagen J.A., Kim S.N., et al. Biofunctionalized Zinc Oxide Field Effect Transistors for Selective Sensing of Riboflavin with Current Modulation // Sensors. — 2011. — V. 11, No. 7. — P. 6645–6655.</mixed-citation><mixed-citation xml:lang="en">Hagen J.A., Kim S.N., et al. Biofunctionalized Zinc Oxide Field Effect Transistors for Selective Sensing of Riboflavin with Current Modulation // Sensors. — 2011. — V. 11, No. 7. — P. 6645–6655.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kohler G., Milstein C. Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity // Nature. — 1975. — V. 256, No. 5517. — P. 495–497.</mixed-citation><mixed-citation xml:lang="en">Kohler G., Milstein C. Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity // Nature. — 1975. — V. 256, No. 5517. — P. 495–497.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lu X., Bai H., et al. A reagentless amperometric immunosensor for alpha-1-fetoprotein based on gold nanowires and ZnO nanorods modified electrode // Analytica Chimica Acta. — 2008. — V. 615, No. 2. — P. 158–164.</mixed-citation><mixed-citation xml:lang="en">Lu X., Bai H., et al. A reagentless amperometric immunosensor for alpha-1-fetoprotein based on gold nanowires and ZnO nanorods modified electrode // Analytica Chimica Acta. — 2008. — V. 615, No. 2. — P. 158–164.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ibupoto Z., Jamal N., Khun K., Willander M. Development of a disposable potentiometric antibody immobilized ZnO nanotubes based sensor for the detection of C-reactive protein // Sensors and Actuators B-Chemical. — 2012. — V. 166. — P. 809–814.</mixed-citation><mixed-citation xml:lang="en">Ibupoto Z., Jamal N., Khun K., Willander M. Development of a disposable potentiometric antibody immobilized ZnO nanotubes based sensor for the detection of C-reactive protein // Sensors and Actuators B-Chemical. — 2012. — V. 166. — P. 809–814.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ahn K.Y., Kwon K., et al. A sensitive diagnostic assay of rheumatoid arthritis using three-dimensional ZnO nanorod structure // Biosensors &amp; Bioelectronics. — 2011. — V. 28, No. 1. — P. 378–385.</mixed-citation><mixed-citation xml:lang="en">Ahn K.Y., Kwon K., et al. A sensitive diagnostic assay of rheumatoid arthritis using three-dimensional ZnO nanorod structure // Biosensors &amp; Bioelectronics. — 2011. — V. 28, No. 1. — P. 378–385.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pearton S.J., Norton D.P., et al. Recent progress in processing and properties of ZnO // Progress in Materials Science. — 2005. — V. 50, No. 3. — P. 293–340.</mixed-citation><mixed-citation xml:lang="en">Pearton S.J., Norton D.P., et al. Recent progress in processing and properties of ZnO // Progress in Materials Science. — 2005. — V. 50, No. 3. — P. 293–340.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Z.L. Nanostructures of zinc oxide // Materials Today. — 2004. — V. 7, No. 6. — P. 26–33.</mixed-citation><mixed-citation xml:lang="en">Wang Z.L. Nanostructures of zinc oxide // Materials Today. — 2004. — V. 7, No. 6. — P. 26–33.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Z.L. The new field of nanopiezotronics // Materials Today. — 2007. — V. 10, No. 5. — P. 20–28.</mixed-citation><mixed-citation xml:lang="en">Wang Z.L. The new field of nanopiezotronics // Materials Today. — 2007. — V. 10, No. 5. — P. 20–28.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ng H.T., Chen B., et al. Optical properties of single-crystalline ZnO nanowires on m-sapphire // Appl. Phys. Lett. — 2003. — V. 82, No. 13. — P. 2023–2025.</mixed-citation><mixed-citation xml:lang="en">Ng H.T., Chen B., et al. Optical properties of single-crystalline ZnO nanowires on m-sapphire // Appl. Phys. Lett. — 2003. — V. 82, No. 13. — P. 2023–2025.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврилов А.И., Капитанова О.О., Баранов А.Н., Чурагулов Б.Р. Особенности гидротермального синтеза ориентированных наностержней оксида цинка на подложке из металлического цинка // Журнал неорганической химии. — 2012. — Т. 57, № 9. — C. 1264–1268.</mixed-citation><mixed-citation xml:lang="en">Гаврилов А.И., Капитанова О.О., Баранов А.Н., Чурагулов Б.Р. Особенности гидротермального синтеза ориентированных наностержней оксида цинка на подложке из металлического цинка // Журнал неорганической химии. — 2012. — Т. 57, № 9. — C. 1264–1268.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Baranov A.N., Panin G.N., Kang T.W., Oh Y.J. Growth of ZnO nanorods from a salt mixture // Nanotechnology. — 2005. — V. 16, No. 9. — P. 1918–1923.</mixed-citation><mixed-citation xml:lang="en">Baranov A.N., Panin G.N., Kang T.W., Oh Y.J. Growth of ZnO nanorods from a salt mixture // Nanotechnology. — 2005. — V. 16, No. 9. — P. 1918–1923.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cozzoli P.D., Kornowski A., Weller H. Colloidal Synthesis of Organic-Capped ZnO Nanocrystals via a Sequential Reduction-Oxidation Reaction // J. Phys. Chem. B. — 2005. — V. 109, No. 7. — P. 2638–2644.</mixed-citation><mixed-citation xml:lang="en">Cozzoli P.D., Kornowski A., Weller H. Colloidal Synthesis of Organic-Capped ZnO Nanocrystals via a Sequential Reduction-Oxidation Reaction // J. Phys. Chem. B. — 2005. — V. 109, No. 7. — P. 2638–2644.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Krishnamoorthy S., Bei T., et al. Morphological and binding properties of interleukin-6 on thin ZnO films grown on (100) silicon substrates for biosensor applications // Biosensors &amp; Bioelectronics. — 2006. — V. 22, No. 5. — P. 707–714.</mixed-citation><mixed-citation xml:lang="en">Krishnamoorthy S., Bei T., et al. Morphological and binding properties of interleukin-6 on thin ZnO films grown on (100) silicon substrates for biosensor applications // Biosensors &amp; Bioelectronics. — 2006. — V. 22, No. 5. — P. 707–714.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Yakimova R., Selegard L., et al. ZnO materials and surface tailoring for biosensing // Frontiers in bioscience (Elite edition). — 2012. — V. 4. — P. 254–278.</mixed-citation><mixed-citation xml:lang="en">Yakimova R., Selegard L., et al. ZnO materials and surface tailoring for biosensing // Frontiers in bioscience (Elite edition). — 2012. — V. 4. — P. 254–278.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Grieshaber D., MacKenzie R., Voeroes J., Reimhult E. Electrochemical biosensors — Sensor principles and architectures // Sensors. — 2008. — V. 8, No. 3. — P. 1400–1458.</mixed-citation><mixed-citation xml:lang="en">Grieshaber D., MacKenzie R., Voeroes J., Reimhult E. Electrochemical biosensors — Sensor principles and architectures // Sensors. — 2008. — V. 8, No. 3. — P. 1400–1458.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврилов А.И., Баранов А.Н., Чурагулов Б.Р., Третьяков Ю.Д. Получение ориентированных наностержней оксида цинка на подложках из металлического цинка гидротермальной обработкой // Доклады Академии Наук Физическая химия. — 2010. — Т. 432, № 4. — С. 486–489.</mixed-citation><mixed-citation xml:lang="en">Гаврилов А.И., Баранов А.Н., Чурагулов Б.Р., Третьяков Ю.Д. Получение ориентированных наностержней оксида цинка на подложках из металлического цинка гидротермальной обработкой // Доклады Академии Наук Физическая химия. — 2010. — Т. 432, № 4. — С. 486–489.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao J., Wu D., Zhi J. A novel tyrosinase biosensor based on biofunctional ZnO nanorod microarrays on the nanocrystalline diamond electrode for detection of phenolic compounds // Bioelectrochemistry. — 2009. — V. 75, No. 1. — P. 44–49.</mixed-citation><mixed-citation xml:lang="en">Zhao J., Wu D., Zhi J. A novel tyrosinase biosensor based on biofunctional ZnO nanorod microarrays on the nanocrystalline diamond electrode for detection of phenolic compounds // Bioelectrochemistry. — 2009. — V. 75, No. 1. — P. 44–49.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Geistlinger H. Electron Theory of Thin-Film Gas Sensors // Sensors and Actuators B-Chemical. — 1993. — V. 17, No. 1. — P. 47–60.</mixed-citation><mixed-citation xml:lang="en">Geistlinger H. Electron Theory of Thin-Film Gas Sensors // Sensors and Actuators B-Chemical. — 1993. — V. 17, No. 1. — P. 47–60.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Zhai T., Li L., et al. Recent Developments in One-Dimensional Inorganic Nanostructures for Photodetectors // Advanced Functional Materials. — 2010. — V. 20, No. 24. — P. 4233–4248.</mixed-citation><mixed-citation xml:lang="en">Zhai T., Li L., et al. Recent Developments in One-Dimensional Inorganic Nanostructures for Photodetectors // Advanced Functional Materials. — 2010. — V. 20, No. 24. — P. 4233–4248.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Неизвестный И.Г. Полупроводниковые нанопроволочные сенсоры // Микроэлектроника. — 2009. — Т. 38, № 4. — С. 243–259.</mixed-citation><mixed-citation xml:lang="en">Неизвестный И.Г. Полупроводниковые нанопроволочные сенсоры // Микроэлектроника. — 2009. — Т. 38, № 4. — С. 243–259.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Плахова Т.В., Шестаков М.В., Баранов А.Н. Влияние текстурированных затравок на морфологию и оптические свойства массивов наностержней оксида цинка, синтезированных из раствора и газовой фазы // Неорганические материалы. — 2012. — Т. 48, № 5. — С. 1–8.</mixed-citation><mixed-citation xml:lang="en">Плахова Т.В., Шестаков М.В., Баранов А.Н. Влияние текстурированных затравок на морфологию и оптические свойства массивов наностержней оксида цинка, синтезированных из раствора и газовой фазы // Неорганические материалы. — 2012. — Т. 48, № 5. — С. 1–8.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Liao Z.M., Xu J., Zhang J.M., Yu D.P. Photovoltaic effect and charge storage in single ZnO nanowires // Appl. Phys. Lett. — 2008. — V. 93, No. 2. — P. 023111–023113.</mixed-citation><mixed-citation xml:lang="en">Liao Z.M., Xu J., Zhang J.M., Yu D.P. Photovoltaic effect and charge storage in single ZnO nanowires // Appl. Phys. Lett. — 2008. — V. 93, No. 2. — P. 023111–023113.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Трошин А.В., Коваленко А.А., Дорофеев С.Г., Баранов А.Н. Сенсибилизация наностержней ZnO квантовыми точками CdSe // Неорганические материалы. — 2012. — Т. 48, № 7. — С. 1–8.</mixed-citation><mixed-citation xml:lang="en">Трошин А.В., Коваленко А.А., Дорофеев С.Г., Баранов А.Н. Сенсибилизация наностержней ZnO квантовыми точками CdSe // Неорганические материалы. — 2012. — Т. 48, № 7. — С. 1–8.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Xu S., Wang Z.L. One-dimensional ZnO nanostructures: Solution growth and functional properties // Nano Research. — 2011. — V. 4, No. 11. — P. 1013–1098.</mixed-citation><mixed-citation xml:lang="en">Xu S., Wang Z.L. One-dimensional ZnO nanostructures: Solution growth and functional properties // Nano Research. — 2011. — V. 4, No. 11. — P. 1013–1098.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
