najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2025-16-4-441-449najo-1443Research ArticlePHYSICSФИЗИКАIonic conductivity in nanopipettes: experiment and modelИонная проводимость в нанопипетках: эксперимент и модельhttps://orcid.org/0000-0002-5356-1261ЛукашенкоС. Ю.LukashenkoS. Yu.

Stanislav Yu. Lukashenko

Saint Petersburg 

lukashenko13@mail.ruhttps://orcid.org/0000-0002-7054-6602ГорбенкоО. М.GorbenkoO. M.

Olga M. Gorbenko

Saint Petersburg

gorolga64@gmail.comhttps://orcid.org/0000-0001-8677-061XФельштынМ. Л.FelshtynM. L.

Mikhail L. Felshtyn

Saint Petersburg 

mfelsztyn@yandex.ruhttps://orcid.org/0000-0003-2575-5015СапожниковИ. Д.SapozhnikovI. D.

Ivan D. Sapozhnikov

Saint Petersburg 

isapojnikov@gmail.comhttps://orcid.org/0000-0002-1571-209XКириленкоД. А.KirilenkoD. A.

Demid A. Kirilenko

Saint Petersburg 

Demid.Kirilenko@mail.ioffe.ruhttps://orcid.org/0000-0002-8578-5200ПичахчиС. В.PichakhchiS. V.

Stepan V. Pichakhchi

Saint Petersburg 

pichakhchi.s@yandex.ruhttps://orcid.org/0000-0003-3361-6947ЖуковМ. В.ZhukovM. V.

Mikhail V. Zhukov

Saint Petersburg 

cloudjyk@yandex.ruhttps://orcid.org/0000-0001-9970-9172ГолубокА. О.GolubokA. O.

Alexander O. Golubok

Saint Petersburg 

aogolubok@mail.ruInstitute for Analytical Instrumentation of the Russian Academy of SciencesRussian FederationIoffe InstituteRussian Federation202503092025164441449Copyright © Lukashenko S.Y., Gorbenko O.M., Felshtyn M.L., Sapozhnikov I.D., Kirilenko D.A., Pichakhchi S.V., Zhukov M.V., Golubok A.O., 20252025Лукашенко С.Ю., Горбенко О.М., Фельштын М.Л., Сапожников И.Д., Кириленко Д.А., Пичахчи С.В., Жуков М.В., Голубок А.О.Lukashenko S.Y., Gorbenko O.M., Felshtyn M.L., Sapozhnikov I.D., Kirilenko D.A., Pichakhchi S.V., Zhukov M.V., Golubok A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/1443

This work investigates ion transport in glass nanopipettes with tip diameters in the range of 80–100 nm, filled with phosphate-buffered saline. A combination of experimental measurements and theoretical modeling is employed. A coupled Poisson-Nernst-Planck-Navier-Stokes model is used to describe the ion transport, incorporating electroosmotic flow, electrophoresis and interionic effects. The theoretical results are in good agreement with experimental current to voltage characteristics. Comparison between modeled and measured data enables estimation of nanopipette geometry with good accuracy. The simulations also reveal characteristic spatial distributions of ionic flow in the aperture area of the nanopipette tip, governed by electroosmosis and the tip shape. These findings provide insights into nanoscale ion transport phenomena relevant for analytical and biological applications.

В этой работе представлено исследование ионной проводимости в стеклянных нанопипетках с внутренними диаметрами при вершине в диапазоне 80–100 нм, заполненных буферным раствором. Используется комбинация экспериментальных измерений и теоретического моделирования. Для описания ионной проводимости использовалась совмещенная модель Пуассона-Нернста-Планка-Навье-Стокса, учитывающая электроосмотический и электрофоретический потоки и эффекты межионного взаимодействия. Рассчитанные значения ионных токов хорошо согласуются с экспериментальными вольт-амперными характеристиками. Сравнение между рассчитанными и измеренными данными позволяет с хорошей точностью оценить внутренний диаметр при вершине нанопипетки. Моделирование также выявляет особенность в пространственном распределении электроосмотического потока в области вершины нанопипетки, управляемую геометрией вершины и апертуры нанопипетки. Полученные результаты предоставляют новые данные об ионной проводимости в наносистемах, важные для разработки аналитических платформ и инструментов на основе нанопипеток для биомедицинских задач.

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The authors declare that there are no conflicts of interest present.