najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2023-14-1-89-97najo-197Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХBioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticlesБиодоступность наноэмульсий, модифицированных куркумином и наночастицами диоксида церияhttps://orcid.org/0000-0001-7742-7027ШирокихА. Д.ShirokikhA. D.

Москва.

Anastasiya D. Shirokikh, Department of Nanomaterials and Nanotechnology,

9, Miusskaya sq., Moscow, 125047. 

adshirokikh@gmail.comhttps://orcid.org/0000-0002-5028-2064АникинаВ. А.AnikinaV. A.

Москва.

Viktoriia A. Anikina,

Institutskaya str., 3, Pushchino, 142290. 

viktoriya.anikina@list.ruhttps://orcid.org/0000-0002-1275-565XЗамятинаЕ. А.ZamyatinaE. A.

Москва.

Elizaveta A. Zamyatina,

Institutskaya str., 3, Pushchino, 142290.

sonyoru162@gmail.comhttps://orcid.org/0000-0003-4443-1569МищенкоЕ. В.MishchenkoE. V.

Москва.

Ekaterina V. Mishchenko, Department of Nanomaterials and Nanotechnology,

Miusskaya sq., 9, Moscow, 125047.

mishchenkoek@list.ruhttps://orcid.org/0000-0002-6931-8434КоролеваМ. Ю.KorolevaM. Yu.

Москва.

Marina Y. Koroleva, Department of Nanomaterials and Nanotechnology,

Miusskaya sq., 9, Moscow, 125047.

m.yu.kor@gmail.comhttps://orcid.org/0000-0003-2343-2140ИвановВ. К.IvanovV. K.

Москва.

Vladimir K. Ivanov,

Leninskiy prosp., 31, Moscow, 119991.

van@igic.ras.ruhttps://orcid.org/0000-0002-0982-6349ПоповаН. Р.PopovaN. R.

Москва.

Nelli R. Popova,

Institutskaya str., 3, Pushchino, 142290.

nellipopovaran@gmail.comMendeleev University of Chemical TechnologyRussian FederationInstitute of Theoretical and Experimental Biophysics of the Russian Academy of SciencesRussian FederationKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of SciencesRussian Federation2023050620251418997Copyright © Shirokikh A.D., Anikina V.A., Zamyatina E.A., Mishchenko E.V., Koroleva M.Y., Ivanov V.K., Popova N.R., 20252025Широких А.Д., Аникина В.А., Замятина Е.А., Мищенко Е.В., Королева М.Ю., Иванов В.К., Попова Н.Р.Shirokikh A.D., Anikina V.A., Zamyatina E.A., Mishchenko E.V., Koroleva M.Y., Ivanov V.K., Popova N.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/197

In this work, the physicochemical properties and biological activity of nanoemulsions prepared from paraffin oil and stabilized by nonionic surfactants as carriers of curcumin and cerium dioxide nanoparticles were studied. An analysis of the results showed that curcumin was incorporated into the oil droplets while cerium dioxide nanoparticles were adsorbed on the surface of oil droplets. The nanoemulsion droplet size did not exceed 100 nm. The absence of toxicity to mouse embryonic fibroblasts in vitro and after a single intraperitoneal injection to mice in vivo makes the nanoemulsions promising drug carriers for advanced biomedical applications.

В работе изучены физико-химические свойства и биологическая эффективность наноэмульсий с углеводородным маслом, стабилизированных неионогенными поверхностно-активными веществами, как носителей активных веществ - куркумина и наночастиц диоксида церия. Анализ физико-химических свойств показал, что куркумин встраивается в структуру масляных капель, а наночастицы диоксида церия адсорбируются на их поверхности. Размер капель наноэмульсий не превышал 100 нм. Отсутствие токсичности в отношении эмбриональных фибробластов мыши in vitro и после однократного внутрибрюшинного введения мышам in vivo делает их перспективными носителями лекарственных средств различного биологического назначения.

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The authors declare that there are no conflicts of interest present.