najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2024-15-6-936-949najo-203Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХNatural polyphenols as potential antibacterial agents and their delivery systems of nanosized levelПриродные полифенолы как потенциальные антибактериальные агенты и их системы доставки наноразмерного уровняhttps://orcid.org/0000-0002-9979-3922КлимшинаВ. И.KlimshinaV. I.

Владислава Игоревна Климшина

Vladislava I. Klimshina

Kronverkskiy pr., 49, bldg. A, St. Petersburg, 197101

https://orcid.org/0009-0005-1721-1044ШайкеновР. О.ShaikenovR. O.

Роман Олегович Шайкенов

RomanO. Shaikenov

Kronverkskiy pr., 49, bldg. A, St. Petersburg, 197101

https://orcid.org/0000-0003-0122-0251МорозкинаС. Н.MorozkinaS. N.

Светлана Николаевна Морозкина

Svetlana N. Morozkina

Kronverkskiy pr., 49, bldg. A, St. Petersburg, 197101

Chernyshevskogo 173, Nalchik

https://orcid.org/0000-0003-3738-408XРомановА. Е.RomanovA. E.

Алексей Евгеньевич Романов

Aleksey E. Romanov

Kronverkskiy pr., 49, bldg. A, St. Petersburg, 197101

https://orcid.org/0000-0001-9949-5709СнетковП. П.SnetkovP. P.

Петр Петрович Снетков

Petr P. Snetkov

Kronverkskiy pr., 49, bldg. A, St. Petersburg, 197101

ppsnetkov@itmo.ruITMO UniversityRussian FederationITMO University; Kabardino-Balkarian State UniversityRussian Federation202405062025156936949Copyright © Klimshina V.I., Shaikenov R.O., Morozkina S.N., Romanov A.E., Snetkov P.P., 20252025Климшина В.И., Шайкенов Р.О., Морозкина С.Н., Романов А.Е., Снетков П.П.Klimshina V.I., Shaikenov R.O., Morozkina S.N., Romanov A.E., Snetkov P.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/203

Bacterial infections associated with multidrug-resistant pathogens are a serious danger to both humans and farm animals. For this reason, natural biologically active agents (BAA), in particular, polyphenols, with a wide range of biological activity could become promising molecules for effective antibacterial therapy. Despite the potentially high antibacterial activity and other beneficial biological effects, the use of such BAA is hindered due to their low water solubility. To overcome this problem, various approaches are used, for example, loading BAA into nanosized delivery systems (nanoparticles, nanocapsules, micelles, etc.). Such approaches allow not only to increase the effectiveness of natural BAA, but also to ensure their targeted (local) effect, which is important in the treatment of bacterial diseases, and in some cases result in synergic action. This review describes the antibacterial properties of the most promising polyphenols and key approaches for their delivery at the nanoscale level, as well as the methods for their development.

Бактериальные инфекции, вызванные патогенами с множественной лекарственной устойчивостью, представляют серьезную опасность как для людей, так и для сельскохозяйственных животных. По этой причине природные биологически активные вещества (БАВ), в частности полифенолы, обладающие широким спектром биологической активности, могут стать перспективными молекулами для эффективной антибактериальной терапии. Несмотря на потенциально высокую антибактериальную активность и другие полезные биологические эффекты, использование таких БАВ затруднено из-за их низкой растворимости в воде. Для преодоления этой проблемы используются различные подходы, например, «загрузка» (инкапсулирование) БАВ в наноразмерные системы доставки (наночастицы, нанокапсулы, мицеллы и т.д.). Такие подходы позволяют не только повысить эффективность природных БАВ, но и обеспечить их адресное (локальное) действие, что важно при лечении бактериальных заболеваний, а в некоторых случаях приводят к синергическому действию. В данном обзоре описаны антибактериальные свойства наиболее перспективных полифенолов и ключевые подходы к их доставке на наноразмерном уровне, а также методы их разработки.

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The authors declare that there are no conflicts of interest present.