najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2023-14-5-560-570najo-294Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХCerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effectsНанокомпозит оксид церия-оксид кремния как мультимодальная платформа для синергетического противоракового действияhttps://orcid.org/0000-0002-1275-565XЗамятинаЕ. А.ZamyatinaE. A.

Elizaveta A. Zamyatina

Institutskaya str., 3, Pushchino, 142290

sonyoru162@gmail.comhttps://orcid.org/0000-0001-8263-889XКотцовС. Ю.KottsovS. Yu.

Sergey Yu. Kottsov

Leninskiy prosp., 31, Moscow, 119991

sergey12-17@yandex.ruhttps://orcid.org/0000-0002-5028-2064АникинаВ. А.AnikinaV. A.

Viktoriia A. Anikina

Institutskaya str., 3, Pushchino, 142290

viktoriya.anikina@list.ruhttps://orcid.org/0000-0003-2643-4846ПоповА. Л.PopovA. L.

Anton L. Popov

Institutskaya str., 3, Pushchino, 142290

antonpopovleonid@gmail.comhttps://orcid.org/0009-0004-7638-5143ШевелеваМ. П.ShevelyovaM. P.

Marina P. Shevelyova

Institutskaya str., 7, Pushchino, 142290

marina.shevelyova@gmail.comhttps://orcid.org/0000-0002-0982-6349ПоповаН. Р.PopovaN. R.

Nelli R. Popova

Institutskaya str., 3, Pushchino, 142290

nellipopovaran@gmail.comInstitute of Theoretical and Experimental Biophysics of the Russian Academy of SciencesRussian FederationKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of SciencesRussian FederationInstitute for Biological Instrumentation of the Russian Academy of SciencesRussian Federation202308062025145560570Copyright © Zamyatina E.A., Kottsov S.Y., Anikina V.A., Popov A.L., Shevelyova M.P., Popova N.R., 20252025Замятина Е.А., Котцов С.Ю., Аникина В.А., Попов А.Л., Шевелева М.П., Попова Н.Р.Zamyatina E.A., Kottsov S.Y., Anikina V.A., Popov A.L., Shevelyova M.P., Popova N.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/294

Cerium oxide nanoparticles (CeNPs) are among the most promising materials with pH-sensitive redox-activity for biomedical nanotechnologies. CeNPs are known to reduce the toxicity of the chemotherapeutic drug doxorubicin (DOX) for normal cells. Here we have proposed and analyzed a new hybrid cerium/silica containing SiNPs@DOX@CeNPs nanocomposite. We showed that the average size of the nanocomposite is 190 nm and it has a spherical shape. The SiNPs@DOX@CeNPs nanocomposite provides effective synergistic anticancer activity of CeNPs with doxorubicin (DOX), as well as selective toxicity against human osteosarcoma (MNNG/HOS) cells in vitro. The SiNPs@DOX@CeNPs nanocomposite may be a good candidate to increase the effectiveness of cancer doxorubicin chemotherapy.

Наночастицы диоксида церия являются одними из наиболее перспективных материалов, обладающих pH-чувствительной окислительно-восстановительной активностью, применяющихся в биомедицинских нанотехнологиях. CeNPs известны своей способностью снижать токсичность химиотерапевтического препарата доксорубицина (DOX) при его инкубации с нормальными клеточными культурами. В работе предложен новый гибридный нанокомпозит SiNPs@DOX@CeNPs. Показано, что нанокомпозит обладал сферической формой, а его размер составил 190 нм. Нанокомпозит SiNPs@DOX@CeNPs обеспечивает синергетическую противоопухолевую активность в отношении клеточной культуры остеосаркомы человека (MNNG/HOS) in vitro. Нанокомпозит SiNPs@DOX@CeNPs может являться хорошим кандидатом для повышения эффективности противоопухолевой терапии с использованием DOX.

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The authors declare that there are no conflicts of interest present.