References

najo

Nanosystems: Physics, Chemistry, Mathematics

Наносистемы: физика, химия, математика

2220-80542305-7971

Университет ИТМО

10.17586/2220-8054-2021-12-1-81-112

najo-372

Research Article

CHEMISTRY AND MATERIALS SCIENCE

ХИМИЯ И НАУКА О МАТЕРИАЛАХ

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Физико-химические и биохимические свойства нанокластерных полиоксомолибдатов типа Кеплерат как перспективных компонентов для биомедицинского применения

Ostroushko

A. A.

Ostroushko

A. A.

Ekaterinburg

alexander.ostroushko@urfu.ru

Grzhegorzhevskii

K. V.

Grzhegorzhevskii

K. V.

Ekaterinburg

Medvedeva

S. Yu.

Medvedeva

S. Yu.

Ekaterinburg

Gette

I. F.

Gette

I. F.

Ekaterinburg

Tonkushina

M. O.

Tonkushina

M. O.

Ekaterinburg

Gagarin

I. D.

Gagarin

I. D.

Ekaterinburg

Danilova

I. G.

Danilova

I. G.

Ekaterinburg

Ural Federal University named after the first President of Russia B.N. YeltsinUral Federal University named after the first President of Russia B.N. Yeltsin

Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of SciencesUral Federal University named after the first President of Russia B.N. Yeltsin; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of SciencesInstitute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

2021

28072025

12181112

2025

Ostroushko A.A., Grzhegorzhevskii K.V., Medvedeva S.Y., Gette I.F., Tonkushina M.O., Gagarin I.D., Danilova I.G.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://nanojournal.ifmo.ru/jour/article/view/372

The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

В статье обсуждаются результаты исследования физико-химических и биохимических свойств нанокластерных полиоксометаллатов молибдена (ПОМ) типа кеплерат, перспективных в области биомедицины в качестве средств адресной доставки лекарственных средств, в том числе транспорта к иммунозависимым органы. ПОМ можно рассматривать как компоненты высвобождающих систем, в том числе пролонгированных с обратной связью (для контроля скорости высвобождения активного компонента лекарственного средства). ПОМ являются многообещающими препаратами для лечения анемии. Также в статье представлены результаты исследований влияния ПОМ на живые системы на молекулярном и клеточном уровнях, на уровне отдельных органов и организма в целом. Механизм и кинетика деструкции ПОМ и возможности стабилизации, проявление колебательных явлений, образование конъюгатов ПОМ с биоактивными веществами, которые могут выделяться при деструкции ПОМ, с полимерными компонентами и с индикаторными флуоресцентными красителями, а также прогнозы рассматриваются дальнейшие исследования.

нанокластерные полиоксомолибдаты кеплератного типафизико-химические и биохимические свойствавоздействие на живые системысредства адресной доставкивысвобождающие системыпролонгированное действие

Keplerate-type nanocluster polyoxomolybdatesphysicochemical and biochemical propertiesimpact on living systemsmeans of targeted deliveryreleasing systemsprolonged action

The paper was prepared in the framework of implementation of the State Assignment from the Ministry of Education and Science of the Russian Federation (Projects Nos. AAAA-A20-120061990010-7 (FEUZ-2020-0052) and AAAA-A18-118020590107-0), as well as of the Program for Increasing Competitiveness of UrFU (financially supported according to the Decree No. 211 of the Government of the Russian Federation, Contract No. 02.A03.21.0006). The research aimed at creating the long-time drug release systems with feedback was carried out within the framework of the project of the Russian Science Foundation No. 19-73-00177.

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The authors declare that there are no conflicts of interest present.