najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2021-12-3-329-335najo-497Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХComprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing applicationКомплексный анализ цитотоксичности полисахаридного гидрогеля, модифицированного наночастицами оксида церия, для применения в заживлении ранPopovA. L.PopovA. L.

Institutskaya str., 3, Pushchino, 142290

Leninskiy prosp., 31, Moscow, 119991

antonpopovleonid@gmail.comAndreevaV. V.AndreevaV. V.

Shchepkina str. 61/2, Moscow, 129110

viktoriaa@yandex.ruKhohlovN. V.KhohlovN. V.

Bolshaya Pirogovskaya str., 19s1, Moscow, 119146

nikolay.khokhlov@gmail.comKamenskikhK. A.KamenskikhK. A.

Institutskaya str., 3, Pushchino, 142290

kristina.kamensk@mail.ruGavrilyukV. B.GavrilyukV. B.

Institutskaya str., 3, Pushchino, 142290

vbg@mail.ruIvanovV. K.IvanovV. K.

Leninskiy prosp., 31, Moscow, 119991

van@igic.ras.ruInstitute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences; Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of SciencesRussian FederationMoscow Regional Research and Clinical Institute, Laboratory of Medical and Physics ResearchRussian FederationI. M. Sechenov First Moscow State Medical UniversityRussian FederationInstitute of Theoretical and Experimental Biophysics of the Russian Academy of SciencesRussian FederationKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of SciencesRussian Federation202104082025123329335Copyright © Popov A.L., Andreeva V.V., Khohlov N.V., Kamenskikh K.A., Gavrilyuk V.B., Ivanov V.K., 20252025Popov A.L., Andreeva V.V., Khohlov N.V., Kamenskikh K.A., Gavrilyuk V.B., Ivanov V.K.Popov A.L., Andreeva V.V., Khohlov N.V., Kamenskikh K.A., Gavrilyuk V.B., Ivanov V.K.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/497

This paper is aimed at the experimental study (in animal models) of acute toxicity and irritating properties of polysaccharide hydrogel modified with cerium oxide nanoparticles. In the acute experiment, there were no indications of irritating action of the gel at the site of application when the hydrogel was administered intragastrically or epicutaneously. No lethal effects were registered during this experiment even at the highest concentration. The results obtained demonstrate the lack of acute toxicity and local irritability of the synthesized hybrid hydrogel, which allows to classify the developed hybrid hydrogel as the relatively low-risk drug.

Целью данной работы является экспериментальное изучение (на животных моделях) острой токсичности и раздражающих свойств полисахаридного гидрогеля, модифицированного наночастицами оксида церия. В остром эксперименте не было признаков раздражающего действия геля в месте аппликации при внутрижелудочном или накожном введении гидрогеля. Летальных эффектов в этом эксперименте не зарегистрировано даже при самой высокой концентрации. Полученные результаты демонстрируют отсутствие у синтезированного гибридного гидрогеля острой токсичности и местного раздражающего действия, что позволяет отнести разработанный гибридный гидрогель к препаратам относительно низкого риска.

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The authors declare that there are no conflicts of interest present.