najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2021-12-4-528-535najo-505Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХConjugation of curcumin with Ag nanoparticle for improving its bioavailability and study of the bioimaging responseКонъюгация куркумина с наночастицами Ag для улучшения его биодоступности и изучения реакции биовизуализацииSarmaRunjunSarmaRunjun

Sector 36, Chandigarh.

runjun2018chd@gmail.comKumar DasMonojKumar DasMonoj

Tezpur, Assam 784028.

SaikiaLakshiSaikiaLakshi

Jorhat, Assam 785006.

RamtekeAnandRamtekeAnand

Tezpur, Assam 784028.

SaikiaRatulSaikiaRatul

Jorhat, Assam 785006.

Department of Physics, Mehr Chand Mahajan DAV College for WomenIndiaCancer Genetics and Chemoprevention Research Group, Department of Molecular Biology and Biotechnology, Tezpur UniversityIndiaMaterial Science and Technology Division, CSIR-North East Institute of Science and TechnologyIndiaBiological Science and Technology Division, CSIR-North East Institute of Science and TechnologyIndia202104082025124528835Copyright © Sarma R., Kumar Das M., Saikia L., Ramteke A., Saikia R., 20252025Sarma R., Kumar Das M., Saikia L., Ramteke A., Saikia R.Sarma R., Kumar Das M., Saikia L., Ramteke A., Saikia R.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/505

We report here the production of curcumin conjugated polyvinylpyrrolidone (PVP)-capped Ag nanoparticles for potential biological applications.

Evidence for the efficient conjugation of hydrophobic curcumin to the synthesized nanoparticles (NPs) is expected from UV-Vis, zeta potential and Fourier transform infrared (FT-IR) analysis. Curcumin conjugated to PVP-capped Ag NPs is observed to gain high water solubility and bioavailability in a biological environment without diminishing its therapeutic properties. The presence of the main therapeutic group, the diarylheptanoid chromophore of curcumin, indicates the existence of its medicinal behavior in the curcumin-Ag NPs complex. Moreover, the fluorescence efficiency of PVP capped Ag NPs in the breast cancer cellular medium have been found to be significantly enhanced (by factor of ∼2.37) with curcumin conjugation. The production of bioavailable curcumin provides an opportunity to expand the clinical repertoire of this efficacious agent without hampering the environment and human health.

Сообщается о производстве конъюгированных с куркумином поливинилпирролидоновых (ПВП) наночастиц Ag для потенциальных биологических применений. Доказательства эффективной конъюгации гидрофобного куркумина с синтезированными наночастицами (НЧ) получены в результате анализа УФ-видимого спектра, дзета-потенциала и инфракрасного преобразования Фурье (FT-IR). Наблюдается, что куркумин, конъюгированный с НЧ Ag, покрытыми ПВП, приобретает высокую растворимость в воде и биодоступность в биологической среде без снижения его терапевтических свойств. Присутствие основной терапевтической группы, диарилгептаноидного хромофора куркумина, указывает на наличие его лечебных свойств в комплексе куркумин – НЧ Ag. Кроме того, было обнаружено, что эффективность флуоресценции НЧ Ag, покрытых ПВП, в клетках рака молочной железы значительно повышается (примерно в 2.37 раза) при конъюгации с куркумином. Производство биодоступного куркумина дает возможность расширить клинический репертуар этого эффективного агента без ущерба для окружающей среды и здоровья человека.

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The authors declare that there are no conflicts of interest present.