najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2021-12-5-575-582najo-517Research ArticlePHYSICSФИЗИКАSurface plasmon resonance optical sensor for COVID-19 detectionОптический датчик на базе поверхностного плазмонного резонанса для обнаружения COVID-19ZainH. A.ZainH. A.

50603 Kuala Lumpur, Malaysia

BatumalayM.BatumalayM.

71800 Nilai, Negeri Sembilan

RahimH. R. A.RahimH. R. A.

Melaka

HarithZ.HarithZ.

71800 Nilai, Negeri Sembilan

YasinM.YasinM.

Surabaya

HarunS. W.HarunS. W.

50603 Kuala Lumpur

Photonics Engineering Laboratory, Department of Electrical Engineering, University of MalayaMalaysiaFaculty of IT, INTI International UniversityMalaysiaFaculty of Electronic and Computer Engineering, Universiti Teknikal Malaysia MelakaMalaysiaFaculty of Engineering and QS, INTI International UniversityMalaysiaDepartment of Physics, Faculty of Science and Technology, Airlangga UniversityIndonesia202105082025125575582Copyright © Zain H.A., Batumalay M., Rahim H.A., Harith Z., Yasin M., Harun S.W., 20252025Zain H.A., Batumalay M., Rahim H., Harith Z., Yasin M., Harun S.W.Zain H.A., Batumalay M., Rahim H.A., Harith Z., Yasin M., Harun S.W.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/517

The transmission of SARS-CoV-2, the novel severe acute respiratory syndrome corona virus have caused the corona virus disease (Covid-19) worldwide pandemic. Overcoming this pandemic requires identifying patients to avoid further spread of the disease. Real-time, sensitive, and costefficient methods for detecting the COVID-19 virus are crucial. Optical sensors provide one such means to achieve this, especially using surface plasmon resonance due to its advantages such as high sensitivity and excellent detection limits. In this paper, we propose a sensor for COVID-19 detection which is based on a simple Kretschmann configuration with gold layers and thiol-tethered DNA for the ligand layer. Angle interrogation was used to obtain the sensitivity of this structure using Matlab numerical analysis. The performance of the sensor was investigated with two types of prisms, SF10 and SF11, while varying the gold layer thickness between 45 – 60 nm. This information was then used to determine which combination of prism and gold thickness are ideal for detecting COVID-19 using thiol-tethered DNA. Thiol-tethered DNA layer sensor showed the highest sensitivity of 137 degree/RIU when a SF10 prism was used with a 50 – 60 nm gold layer and thiol tethered DNA layer.

Передача SARS-CoV-2, нового коронирусного вируса тяжелого острого респираторного синдрома, вызвала всемирную пандемию коронавирусной болезни (Covid-19). Преодоление этой пандемии требует выявления пациентов, чтобы избежать дальнейшего распространения болезни. Решающее значение имеют чувствительные и экономичные методы обнаружения вируса COVID-19 в режиме реального времени. Одним из таких средств для достижения этого являются оптические датчики, особенно с использованием поверхностного плазмонного резонанса из-за его преимуществ, таких как высокая чувствительность и отличные пределы обнаружения. В этой статье мы предлагаем датчик для обнаружения COVID-19, основанный на простой конфигурации Кречмана со слоями золота и ДНК, связанной с тиолами, для слоя лиганда. Угловой проверка была использована для получения чувствительности этой структуры с использованием численного анализа Matlab. Работа датчика исследовалась с двумя типами призм, SF10 и SF11, при изменении толщины слоя золота в пределах 45-60 нм. Затем эта информация использовалась для определения того, какая комбинация призмы и толщины золота идеально подходит для обнаружения COVID-19 с использованием ДНК, связанной тиолом. Датчик слоя ДНК, связанный тиолом, показал самую высокую чувствительность 137 градусов/RIU, когда использовалась призма SF10 со слоем золота 50–60 нм и слоем ДНК, связанной тиолом.

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The authors declare that there are no conflicts of interest present.