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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">najo</journal-id><journal-title-group><journal-title xml:lang="en">Nanosystems: Physics, Chemistry, Mathematics</journal-title><trans-title-group xml:lang="ru"><trans-title>Наносистемы: физика, химия, математика</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-8054</issn><issn pub-type="epub">2305-7971</issn><publisher><publisher-name>Университет ИТМО</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17586/2220-8054-2017-8-3-391-396</article-id><article-id custom-type="elpub" pub-id-type="custom">najo-618</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CHEMISTRY AND MATERIALS SCIENCE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИМИЯ И НАУКА О МАТЕРИАЛАХ</subject></subj-group></article-categories><title-group><article-title>Biological effect of zirconium dioxide-based nanoparticles</article-title><trans-title-group xml:lang="ru"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Almjasheva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="en"><p>ul. Professora Popova 5, 197376 St. Petersburg</p></bio><email xlink:type="simple">almjasheva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Garabadzhiu</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="en"><p>Moskovsky prospect 26, 190013 St. Petersburg</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Kozina</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="en"><p>Moskovsky prospect 26, 190013 St. Petersburg</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Litvinchuk</surname><given-names>L. F</given-names></name></name-alternatives><bio xml:lang="en"><p>Pudozhskaya ul. 7, 197110 St. Petersburg</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="western" xml:lang="en"><surname>Dobritsa</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="en"><p>Pudozhskaya ul. 7, 197110 St. Petersburg</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="en" id="aff-1"><institution>1St. Petersburg Electrotechnical University “LETI”</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-2"><institution>St. Petersburg State Technological Institute (Technical university)</institution><country>Russian Federation</country></aff><aff xml:lang="en" id="aff-3"><institution>State Research Institute of Highly Pure Biopreparations of the Federal Medical Biological Agency FMB</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>11</day><month>08</month><year>2025</year></pub-date><volume>8</volume><issue>3</issue><fpage>391</fpage><lpage>396</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Almjasheva O.V., Garabadzhiu A.V., Kozina Y.V., Litvinchuk L.F., Dobritsa V.P., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Almjasheva O.V., Garabadzhiu A.V., Kozina Y.V., Litvinchuk L.F., Dobritsa V.P.</copyright-holder><copyright-holder xml:lang="en">Almjasheva O.V., Garabadzhiu A.V., Kozina Y.V., Litvinchuk L.F., Dobritsa V.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://nanojournal.ifmo.ru/jour/article/view/618">https://nanojournal.ifmo.ru/jour/article/view/618</self-uri><abstract><p>This work demonstrates the positive effects of zirconium dioxide nanoparticles on cells in vitro. This is supported by the absence of toxicity, stimulation of metabolic and proliferative activity. The nanoparticles of solid solution of europium oxide in europium dioxide do not exhibit an explicit biological effect. The potentially successful application of zirconium dioxide-based nanoparticles in pharmacology has been demonstrated.</p></abstract><kwd-group xml:lang="en"><kwd>zirconium dioxide</kwd><kwd>europium oxide</kwd><kwd>nanoparticles</kwd><kwd>toxicity</kwd><kwd>metabolic activity</kwd><kwd>proliferative activity</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The authors express their gratitude to V. V. Gusarov for the attention he paid to the work and for his help in the interpretation of the results. 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