najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2017-8-6-760-781najo-662Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХCerium dioxide nanoparticles as third-generation enzymes (nanozymes)Cerium dioxide nanoparticles as third-generation enzymes (nanozymes)PopovA. L.PopovA. L.

Pushchino, Moscow region, 142290

Pushchino, Moscow region, 142290

ShcherbakovA. B.ShcherbakovA. B.

Kyiv D0368

Kyiv D0368

ZholobakN. M.ZholobakN. M.

Kyiv D0368

Kyiv D0368

BaranchikovA. Ye.BaranchikovA. Ye.

Moscow 119991

Moscow 119991

IvanovV. K.IvanovV. K.

Moscow 119991

Moscow 119991

van@igic.ras.ruInstitute of Theoretical and Experimental Biophysics, Russian Academy of SciencesInstitute of Theoretical and Experimental Biophysics, Russian Academy of SciencesZabolotny Institute of Microbiology and Virology, National Academy of Sciences of UkraineZabolotny Institute of Microbiology and Virology, National Academy of Sciences of UkraineKurnakov Institute of General and Inorganic Chemistry of Russian Academy of SciencesKurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences20171208202586760781Copyright © Popov A.L., Shcherbakov A.B., Zholobak N.M., Baranchikov A.Y., Ivanov V.K., 20252025Popov A.L., Shcherbakov A.B., Zholobak N.M., Baranchikov A.Y., Ivanov V.K.Popov A.L., Shcherbakov A.B., Zholobak N.M., Baranchikov A.Y., Ivanov V.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/662

Ceria nanoparticles are capable of performing the function of some enzymes (such as oxidoreductases, phosphatase) and can be classified as nanozymes. In this review, the actual data on the enzymatic activity of ceria were critically analyzed and specific conditions under which the cerium dioxide nanoparticles can act as enzymes were defined. The presented analysis may be useful in the planning, design and synthesis of ceria nanoparticles having the desired enzymatic functions required for various processes, including the development of the nanodrugs, which exhibit the therapeutic effect depending on their composition and pH of media, development of molecular sensors and biosensors, etc.

Ceria nanoparticles are capable of performing the function of some enzymes (such as oxidoreductases, phosphatase) and can be classified as nanozymes. In this review, the actual data on the enzymatic activity of ceria were critically analyzed and specific conditions under which the cerium dioxide nanoparticles can act as enzymes were defined. The presented analysis may be useful in the planning, design and synthesis of ceria nanoparticles having the desired enzymatic functions required for various processes, including the development of the nanodrugs, which exhibit the therapeutic effect depending on their composition and pH of media, development of molecular sensors and biosensors, etc.

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The authors declare that there are no conflicts of interest present.