najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2017-8-2-282-289najo-677Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХLayer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agentsPopovaN. R.

Institutskaya, 3, Pushchino 142290

nellipopovaran@gmail.comPopovA. L.

Institutskaya, 3, Pushchino 142290

antonpopovleonid@gmail.comShcherbakovA. B.

Str. Zabolotnogo, 154, Kyiv D0368

carotene@igic.ras.ruIvanovV. K.

Leninsky av, 31, Moscow 119991; Lenin str., 36, Tomsk 634050

van@igic.ras.ruInstitute of theoretical and experimental biophysics of the Russian Academy of SciencesRussian FederationZabolotny Institute of Microbiology and Virology, National Academy of Sciences of UkraineUkraineKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences; National Research Tomsk State UniversityRussian Federation20171208202582282289Copyright © Popova N.R., Popov A.L., Shcherbakov A.B., Ivanov V.K., 20252025Popova N.R., Popov A.L., Shcherbakov A.B., Ivanov V.K.Popova N.R., Popov A.L., Shcherbakov A.B., Ivanov V.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/677

Modern methods of cancer treatment include chemotherapy and radiotherapy, but they are often characterized by low efficacy and high toxicity. The effectiveness of cancer therapy is often limited by a lack of effective systems for drug delivery to the tumor site. Cerium oxide nanoparticles are able to act as radioprotectors and as radiosensitizers exhibiting selective toxicity in the tumor microenvironment, providing for their tremendous potential in treating cancer. However, methods for controlled delivery of CeO2 nanoparticles to the tumor have not been investigated nor described yet. In this article, we consider different approaches to the development of new ceria nanoparticle-based theranostic agents. Modification of polyelectrolyte microcapsules with nano-ceria appears to be the most promising method. Our design proposals are based on the synergistic pharmacological action of ceria-based nanomaterials and anticancer pharmaceuticals with the ability to control and visualize their sites of localization.

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The authors declare that there are no conflicts of interest present.