najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2018-9-2-290-294najo-710Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХParticle size analysis of niosomes as a function of temperatureDiskaevaE. I.

Mira, 310, Stavropol, 355017

VecherO. V.

Mira, 310, Stavropol, 355017

vecher.olga@mail.ruBazikovI. A.

Mira, 310, Stavropol, 355017

VakalovD. S.

Pushkina, 1, Stavropol, 355000

Stavropol State Medical UniversityRussian FederationNorth Caucasus Federal UniversityRussian Federation20181208202592290–294Copyright © Diskaeva E.I., Vecher O.V., Bazikov I.A., Vakalov D.S., 20252025Diskaeva E.I., Vecher O.V., Bazikov I.A., Vakalov D.S.Diskaeva E.I., Vecher O.V., Bazikov I.A., Vakalov D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/710

The aim of the present investigation is to study and evaluate influence of temperature factor on the size of niosomes and particle size distribution. Particle size was defined with analysis electronic microscopy images. By the analysis of the probability density functions and cumulative distribution functions for particle size was confirmed influence temperature on their equivalent diameter. On the basis of the statistical analysis, we proved possibility of management niosomes size using the change temperature on the niosomes dispersion.

niosomes dispersionnonionic surfactant vesiclesparticle size distributionReferencesGrowi R., Balaji P., Vijayalakshmi P., Preethy Mol.G., Karthik Raja P. Niosomes – a vesicular drug delivery system. International Journal of Current Research. 2013, 5(08), P. 2239–2244.Growi R., Balaji P., Vijayalakshmi P., Preethy Mol.G., Karthik Raja P. Niosomes – a vesicular drug delivery system. International Journal of Current Research. 2013, 5(08), P. 2239–2244.Viviane F. Naggar, Safaa S. Elgamal, Ahmed N. Allam Formulation and Physicochemical Characterization. Journal of American Science, 2012, 8(9), P. 417–428.Viviane F. Naggar, Safaa S. Elgamal, Ahmed N. Allam Formulation and Physicochemical Characterization. Journal of American Science, 2012, 8(9), P. 417–428.Abhinav Kumar, Pal Jogender Lal, Jaiswal Amit, Singh Vishwabban. Review of niosomes as novel druid delivery system. Int. Research Journal of Pharmacy, 2(5) 2011, P. 61–65.Abhinav Kumar, Pal Jogender Lal, Jaiswal Amit, Singh Vishwabban. Review of niosomes as novel druid delivery system. Int. Research Journal of Pharmacy, 2(5) 2011, P. 61–65.Zerrin Sezgin Bayindir, Nilufer Yuksel. Characterization of niosomes Prepared with various Nonionic Surfactants for paclitaxel Oral delivery. Journal of Pharmaceutical sciences, 2010, 99(4), P. 2049–2060.Zerrin Sezgin Bayindir, Nilufer Yuksel. Characterization of niosomes Prepared with various Nonionic Surfactants for paclitaxel Oral delivery. Journal of Pharmaceutical sciences, 2010, 99(4), P. 2049–2060.Bazikov I.A. A method for transdermal transfer of active substances using niosomes on the basis of PEG-12 dimethicone. RF patent 2539396, 2014.Bazikov I.A. A method for transdermal transfer of active substances using niosomes on the basis of PEG-12 dimethicone. RF patent 2539396, 2014.Bazikov I.A., Zelensky V.A., Gukasyan A.L. Nanobiotechnologies of the use of niosomes in dentistry, Maikop: Quality, 2015, 112 p.Bazikov I.A., Zelensky V.A., Gukasyan A.L. Nanobiotechnologies of the use of niosomes in dentistry, Maikop: Quality, 2015, 112 p.Malay K. Das, Narahari N. Palei. Sorbitan ester niosomes for topical delivery of rofecoxib. Indian Journal of Experimental Biology, 2011, 49, P. 438–445.Malay K. Das, Narahari N. Palei. Sorbitan ester niosomes for topical delivery of rofecoxib. Indian Journal of Experimental Biology, 2011, 49, P. 438–445.Sakthivel M., Kannan K., Manavalan R., Senthamarai R. Non Ionic Surfactant Vesicles. A Review. Research Journal Pharmaceutical, Biological and Chemical, 2012, 3(01), P. 604–614.Sakthivel M., Kannan K., Manavalan R., Senthamarai R. Non Ionic Surfactant Vesicles. A Review. Research Journal Pharmaceutical, Biological and Chemical, 2012, 3(01), P. 604–614.Handbook of nanostructured materials and nanotechnology. Ed. H.S. Nalwa. Boston: Academic Press, 2000, 3461 p.Handbook of nanostructured materials and nanotechnology. Ed. H.S. Nalwa. Boston: Academic Press, 2000, 3461 p.Gannu P. Kumar, Pogaku Rajieshwarrao. Nonionic Surfactants vesicular system for effective druid delivery – an overview. Acta Pharmaceutica Simca B, 2011, 1(4), P. 208–219.Gannu P. Kumar, Pogaku Rajieshwarrao. Nonionic Surfactants vesicular system for effective druid delivery – an overview. Acta Pharmaceutica Simca B, 2011, 1(4), P. 208–219.Apeora Agarwal, Weha Jugal, Gauree Kukreti, Sachdew Yadav. Niosomes of targeted druid delivery systems. International Journal of Pharmaceutical Science Review and Research, 2012, 12(1), P. 53–60.Apeora Agarwal, Weha Jugal, Gauree Kukreti, Sachdew Yadav. Niosomes of targeted druid delivery systems. International Journal of Pharmaceutical Science Review and Research, 2012, 12(1), P. 53–60.Ahuja N., Saini V., Bishnoi V.K., Garg A., Hisoria M., Sharma J., et al. Formulation and evaluation of lansoprazol noisome. Rasayan J. Chem., 2008, 1, P. 561–564.Ahuja N., Saini V., Bishnoi V.K., Garg A., Hisoria M., Sharma J., et al. Formulation and evaluation of lansoprazol noisome. Rasayan J. Chem., 2008, 1, P. 561–564.Zerrin Sezgin Bayindir, Nilufer Yuksel. Investigation of formulation variables and excipient interaction on the production of niosomes. Pharm. Sci. Tech., 2012, 13, P. 826–835.Zerrin Sezgin Bayindir, Nilufer Yuksel. Investigation of formulation variables and excipient interaction on the production of niosomes. Pharm. Sci. Tech., 2012, 13, P. 826–835.Arunothayanum P. et al. Extrusion of niosomes from capillaries approaches to a pulsed delivery device. J. Cont Release, 1999, 60, P. 1999.Arunothayanum P. et al. Extrusion of niosomes from capillaries approaches to a pulsed delivery device. J. Cont Release, 1999, 60, P. 1999.Bazikov I.A., Beyer E.V., Maltsev A.N., et al. Investigation of the cardiotoxicity of the niosomal form of doxorubicin. Medical Gazette of the North Caucasus, 2016, 11(3), P. 421–424.Bazikov I.A., Beyer E.V., Maltsev A.N., et al. Investigation of the cardiotoxicity of the niosomal form of doxorubicin. Medical Gazette of the North Caucasus, 2016, 11(3), P. 421–424.Bazikov I.A., Lukinova V.V., Maltsev A.N., et al. The interaction of niosomal doxorubicin with cell membranes. Medical Gazette of the North Caucasus, 2016, 11(1), P. 108–110.Bazikov I.A., Lukinova V.V., Maltsev A.N., et al. The interaction of niosomal doxorubicin with cell membranes. Medical Gazette of the North Caucasus, 2016, 11(1), P. 108–110.Bazikov I.A., Lukinova V.V., Malinina N.I., Maltsev A.N. Study of the mechanisms of intercellular interaction of the niosomal form of the antitumor drug doxorubicin with plasma membranes. The Eurasian Union of Scientists, 2016, 3(24), P. 34.Bazikov I.A., Lukinova V.V., Malinina N.I., Maltsev A.N. Study of the mechanisms of intercellular interaction of the niosomal form of the antitumor drug doxorubicin with plasma membranes. The Eurasian Union of Scientists, 2016, 3(24), P. 34.Bazikov I.A., Omelyanchuk P.A. The method of delivery of biologically active substances with the help of niosomes RF patent 2320323, 2008.Bazikov I.A., Omelyanchuk P.A. The method of delivery of biologically active substances with the help of niosomes RF patent 2320323, 2008.

The authors declare that there are no conflicts of interest present.