najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2018-9-4-537-543najo-768Research ArticleCHEMISTRY AND MATERIAL SCIENCEХИМИЯ И МАТЕРИАЛОВЕДЕНИЕСerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitroShydlovskaO.

Kyiv

olgashydlovska@gmail.comKharchenkoE.

Kyiv

yugin171094@gmail.comZholobakN.

Kyiv

n.zholobak2018@gmail.comShcherbakovA.

Kyiv

ceroform@gmail.comMaryninA.

Kyiv

andriimarynin@ukr.netIvanovaO.

Moscow

runetta05@mail.ruBaranchikovA

Moscow

a.baranchikov@yandex.ruIvanovV.

Moscow

Tomsk

van@igic.ras.ruZabolotny Institute of Microbiology and Virology NANUUkraineNational University of Food TechnologiesUkraineKurnakov Institute of General and Inorganic ChemistryRussian FederationKurnakov Institute of General and Inorganic Chemistry; National Research Tomsk State UniversityRussian Federation20181308202594537543Copyright © Shydlovska O., Kharchenko E., Zholobak N., Shcherbakov A., Marynin A., Ivanova O., Baranchikov A., Ivanov V., 20252025Shydlovska O., Kharchenko E., Zholobak N., Shcherbakov A., Marynin A., Ivanova O., Baranchikov A., Ivanov V.Shydlovska O., Kharchenko E., Zholobak N., Shcherbakov A., Marynin A., Ivanova O., Baranchikov A., Ivanov V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/768

Cerium oxide nanoparticles (CeONP) were used as the modifying agent for the recombinant tumor necrosis factor-α and recombinant tumor necrosis factor-α-thymosin-α1 (rhTNF and rhTNF-T). A notable increase of the biological activity of proteins with antitumor effect was demonstrated. It was established that the cytotoxicity of rTNF-T+CeONP composite increases with the duration of exposure to 7 days. Modification of rTNF-T with cerium oxide nanoparticles provides a stronger and more stable cytotoxic effect in Hep-2, L929, and A-549 tumor cell lines.

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The authors declare that there are no conflicts of interest present.