najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМОnajo-875Research ArticleFULLERENSFULLERENSToward paclitaxel-[60]fullerene immunoconjugates as a targeted prodrug against cancerMackeyevY.

Department of Chemistry and The Smalley Institute for Nanoscale Science & Technology

Houston

RaoofM.

Department of Surgical Oncology

Houston

CisnerosB.

Department of Chemistry and The Smalley Institute for Nanoscale Science & Technology; Department of Surgical Oncology

Houston

KoshkinaN.

Department of Surgical Oncology

Houston

BergerC. S.

Department of Chemistry and The Smalley Institute for Nanoscale Science & Technology

Houston

WilsonL. J.

Department of Chemistry and The Smalley Institute for Nanoscale Science & Technology

Houston

CurleyS. A.

Baylor College of Medicine

MS390, Houston, TX 77030

Rice UniversityUnited StatesThe University of Texas M. D. Anderson Cancer CenterUnited StatesRice University; The University of Texas M. D. Anderson Cancer CenterUnited StatesOne Baylor PlazaUnited States201415082025516775Copyright © Mackeyev Y., Raoof M., Cisneros B., Koshkina N., Berger C.S., Wilson L.J., Curley S.A., 20252025Mackeyev Y., Raoof M., Cisneros B., Koshkina N., Berger C.S., Wilson L.J., Curley S.A.Mackeyev Y., Raoof M., Cisneros B., Koshkina N., Berger C.S., Wilson L.J., Curley S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/875

Two newly synthesized water-soluble conjugates of Paclitaxel with malonodiserinolamide-derivatized [60]fullerene (C60-ser) undergo hydrolysis and release their medical payload under biological conditions. In vivo testing of one of these compounds in a murine model showed tumor volume reduction similar to the FDA-approved drug Abraxane, but without the associated weight-loss, indicating better tolerance of this new formulation.

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The authors declare that there are no conflicts of interest present.