najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2018-9-3-430-438najo-878Research ArticleCHEMISTRY AND MATERIAL SCIENCEХИМИЯ И МАТЕРИАЛОВЕДЕНИЕCytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cellsPopovA. L.

Pushchino, Moscow region, 142290

SavintsevaI. V.

Pushchino, Moscow region, 142290

MysinaE. A.

Pushchino, Moscow region, 142290

ShcherbakovA. B.

Kyiv D0368

PopovaN. R.

Pushchino, Moscow region, 142290

IvanovaO. S.

Moscow 119991

KolmanovichD. D.

Nalchik, 360004

IvanovV. K.

Moscow 119991

Moscow 119991

van@igic.ras.ruInstitute of Theoretical and Experimental Biophysics, Russian Academy of SciencesRussian FederationZabolotny Institute of Microbiology and Virology, National Academy of Sciences of UkraineUkraineKurnakov Institute of General and Inorganic Chemistry of Russian Academy of SciencesRussian FederationKabardino-Balkarian State UniversityRussian FederationKurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences; Moscow Technological University, Institute of Fine Chemical TechnologiesRussian Federation20181408202593430438Copyright © Popov A.L., Savintseva I.V., Mysina E.A., Shcherbakov A.B., Popova N.R., Ivanova O.S., Kolmanovich D.D., Ivanov V.K., 20252025Popov A.L., Savintseva I.V., Mysina E.A., Shcherbakov A.B., Popova N.R., Ivanova O.S., Kolmanovich D.D., Ivanov V.K.Popov A.L., Savintseva I.V., Mysina E.A., Shcherbakov A.B., Popova N.R., Ivanova O.S., Kolmanovich D.D., Ivanov V.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/878

A complex analysis of cytotoxicity was performed for a nanodispersed sol of cerium dioxide doped with gadolinium (Ce0.8Gd0.2O2−x) using a culture of mesenchymal stem cells. The absence of cyto- and genotoxicity over a wide range of concentrations (10−5 – 10−9 M) was demonstrated. At that, the highest concentration of Ce0.8Gd0.2O2−x nanoparticles (10−4 M) was found to slightly reduce the activity of intracellular dehydrogenase, yet not leading to the development of apoptosis and further cell death. The obtained results confirm a high degree of Ce0.8Gd0.2O2−x nanoparticle biocompatibility, which opens prospects for their safe application as a contrasting agent in the magnetic resonance tomography.

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The authors declare that there are no conflicts of interest present.