najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМО10.17586/2220-8054-2025-16-1-74-88najo-93Research ArticleCHEMISTRY AND MATERIALS SCIENCEХИМИЯ И НАУКА О МАТЕРИАЛАХIsomeric protected dipeptides generated stable bio-compatible gold nanoparticlesИзомерные защищенные дипептиды, генерирующие стабильные биосовместимые золотые наночастицыhttps://orcid.org/0000-0002-0469-3399СудешнаКарSudeshnaKar

Sudeshna Kar – Assistant Professor, Department of Basic Science and Humanities (Chemistry)

4, Diamond Harbour Rd, Alipore Body Guard Lines, Khidirpur, Kolkata, West Bengal700023, Kolkata

06.sudeshna@gmail.comhttps://orcid.org/0000-0001-7000-6086ЙианТайYianTai

Yian Tai – Professor, Department of Chemical Engineering

43 Keelung Road, Taipei-106

ytai@mail.ntust.edu.twSt. Thomas College of Engineering and TechnologyRussian FederationNational Taiwan University of Science and TechnologyTaiwan, Province of China2025010620251617488Copyright © Sudeshna K., Yian T., 20252025Судешна К., Йиан Т.Sudeshna K., Yian T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/93

It has been observed that two isomeric protected dipeptides which show altered nano-morphologies under similar conditions but behave unaltered to form stable gold nano-particles (AuNPs) having similar shape and size; whereas both the peptides showed fluctuating bio-compatibility but after conjugation with AuNP they show stable bio-compatibility. These gold nano conjugates are very stable, even up to 2 months the AuNPs showed no change in size or shape. Using a straightforward and reproducible one-pot synthetic technique, we were able to produce stable biocompatible gold nanoparticles using two isomeric protected dipeptides.

Было замечено, что два изомерных защищенных дипептида, которые показывают измененную наноморфологию в схожих условиях, но ведут себя неизменными, образуя стабильные золотые наночастицы (AuNP), имеющие схожую форму и размер; тогда как оба пептида показали флуктуирующую биосовместимость, но после конъюгации с AuNP они показывают стабильную биосовместимость. Эти золотые наноконъюгаты очень стабильны, даже до 2 месяцев AuNP не показывали никаких изменений в размере или форме. Используя простую и воспроизводимую технику однореакторного синтеза, мы смогли получить стабильные биосовместимые золотые наночастицы с использованием двух изомерных защищенных дипептидов. 

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The authors declare that there are no conflicts of interest present.