najoNanosystems: Physics, Chemistry, MathematicsНаносистемы: физика, химия, математика2220-80542305-7971Университет ИТМОnajo-982Research ArticleOTHERSOTHERSUsing artificial neural networks for elaboration of fluorescence biosensors on the basis of nanoparticlesBurikovS. A.

Physics Department

Moscow

burikov@lid.phys.msu.ruDolenkoS. A.

Moscow

dolenko@srd.sinp.msu.ruLaptinskiyK. A.

Physics Department

Moscow

laptinsky@lid.phys.msu.ruPlastininI. V.

Physics Department

Moscow

VervaldA. M.

Physics Department

Moscow

vervald@lid.phys.msu.ruVlasovI. I.

Moscow

vlasov@nsc.gpi.ruDolenkoT. A.

Physics Department

Moscow

tdolenko@lid.phys.msu.ruMoscow M. V. Lomonosov State UniversityRussian FederationD. V. Skobeltsyn Institute of Nuclear Physics, Moscow State UniversityRussian FederationGeneral Physics Institute RASRussian Federation20141508202551195202Copyright © Burikov S.A., Dolenko S.A., Laptinskiy K.A., Plastinin I.V., Vervald A.M., Vlasov I.I., Dolenko T.A., 20252025Burikov S.A., Dolenko S.A., Laptinskiy K.A., Plastinin I.V., Vervald A.M., Vlasov I.I., Dolenko T.A.Burikov S.A., Dolenko S.A., Laptinskiy K.A., Plastinin I.V., Vervald A.M., Vlasov I.I., Dolenko T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nanojournal.ifmo.ru/jour/article/view/982

In this study, the results for the solution of the pattern recognition problem are presented — extraction of fluorescence contribution for carbon dots used as biomarkers from the background signals of natural fluorophores and the determination of relative nanoparticle concentration. To solve this problem, artificial neural networks were used. The principal opportunity for solution of the given problem was demonstrated. The used architectures for neural networks allow the detection of carbon dot-based fluorescence within the background of native fluorescent egg protein with sufficiently high accuracy (not lower than 0.002 mg/ml).

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The authors declare that there are no conflicts of interest present.