Cerium oxide nanoparticles provide radioprotective effects upon X-ray irradiation by modulation of gene expression
https://doi.org/10.17586/2220-8054-2019-10-5-564-572
Abstract
Nanocrystalline cerium dioxide is known as a unique redox active nanomaterial. Cerium dioxide is considered as the basis for future biomedical preparations, including radioprotectors. In the framework of this study, we synthesized citrate-stabilized CeO2 nanoparticles and carried out a comprehensive in vitro assessment of their radioprotective properties on a NCTC L929 murine fibroblast culture. It was shown that CeO2 nanoparticles ensure the survival of murine fibroblasts, even after high-dose X-ray irradiation, reducing the number of dead cells in the culture and modulating the mRNA level of the key antioxidant enzymes – superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2). The results obtained confirm the potential for studying the properties of CeO2 nanoparticles as basic materials for designing new efficient and safe preparations for protection against ionizing radiation.
About the Authors
N. R. Popova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
N. R. Popova
Pushchino, Moscow region, 142290
T. O. Shekunova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
T. O. Shekunova
Moscow, 119991
A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
A. L. Popov
Pushchino, Moscow region, 142290
I. I. Selezneva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
I.I. Selezneva
Pushchino, Moscow region, 142290
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
V. K. Ivanov
Moscow, 119991
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Review
For citations:
Popova N.R., Shekunova T.O., Popov A.L., Selezneva I.I., Ivanov V.K. Cerium oxide nanoparticles provide radioprotective effects upon X-ray irradiation by modulation of gene expression. Nanosystems: Physics, Chemistry, Mathematics. 2019;10(5):564-572. https://doi.org/10.17586/2220-8054-2019-10-5-564-572
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