Carbon dots with media-independent fluorescence
https://doi.org/10.17586/2220-8054-2025-16-6-915-918
Abstract
Since their discovery, carbon dots have been of great scientific interest due to their unique properties, including strong fluorescence and biocompatibility, which determine their potential application in biosensorics, bioimaging, drug delivery, and many other fields. This paper presents a new approach for the synthesis of high quantum yield carbon dots with media-independent fluorescence developed in the process of searching for solutions to the problem of carbon dot’s application in immunochromatographic analysis.
About the Authors
P. D. NasirovRussian Federation
Pavel D. Nasirov
19, Dubna, 141980
S. A. Novikova
Russian Federation
Sagila A. Novikova
19, Dubna, 141980
E. D. Gribova
Russian Federation
Elena D. Gribova
19, Dubna, 141980
P. P. Gladyshev
Russian Federation
Pavel P. Gladyshev
19, Dubna, 141980
I. V. Mukhina
Russian Federation
Irina V. Mukhina
19, Dubna, 141980
References
1. Martinez-Liu C., et al. Development of a rapid gold nanoparticle-based lateral flow immunoassay for the detection of dengue virus. Biosensors, 2022, 12 (7), 495.
2. Prakashan D., et al. Gold nanoparticle conjugate-based lateral flow immunoassay (LFIA) for rapid detection of RBD antigen of SARS-CoV-2 in clinical samples using a smartphone-based application. J. of Medical Virology, 2023, 95 (1), 28416.
3. Chen Z., et al. Selective surface passivation of gold nanoparticles: A strategy for enhanced sensitivity in lateral flow immunoassay. Chemical Engineering J., 2025, 503, 158571.
4. Li J., et al. Quantum Dots for Chemical Metrology. Analytical Chemistry, 2025, 97 (13), P. 6891–6910.
5. Li J., et al. Dual protecting encapsulation synthesis of ultrastable quantum-dot nanobeads for sensitive and accurate detection of cardiac biomarkers. Sensors and Actuators B: Chemical, 2021, 344, 130275.
6. Schuller M., et al. Investigating conjugated polymer nanoparticle formulations for lateral flow immunoassays. ¨ RSC advances, 2021, 11 (47), P. 29816–29825.
7. Zor E., et al. Carbon dots in the detection of pathogenic bacteria and viruses. Critical Reviews in Analytical Chemistry, 2024, 54 (2), P. 219–246.
8. Zhang G., et al. Novel Reporter Based on Aggregation-induced emission Luminogens for Lateral Flow Immunoassay: A Mini Review. TrAC Trends in Analytical Chemistry, 2024, 118098.
9. Devi J.S.A., et al. Luminescent carbon dots versus quantum dots and gold nanoclusters as sensors. Nanoscale Horizons, 2024, 9 (10), P. 1683–1702.
10. Thomas D., et al. Solvatochromic and pH-sensitive fluorescent membrane probes for imaging of live cells. ACS Chemical Neuroscience, 2021, 12 (4), P. 719–734.
11. Alas M.O., Genc R. Solvatochromic surface-passivated carbon dots for fluorometric moisture sensing in organic solvents. ACS Applied Nano Materials, 2021, 4 (8), P. 7974–7987.
12. Singhal P., Vats B.G., Pulhani V. Origin of solvent and excitation dependent emission in newly synthesized amphiphilic carbon dots. J. of Luminescence, 2022, 244, 118742.
13. Lakowicz J.R. (ed.). Principles of fluorescence spectroscopy. Boston, MA, Springer US, 2006.
14. Ludmerczki R., et al. Carbon dots from citric acid and its intermediates formed by thermal decomposition. Chemistry–A European J., 2019, 25 (51), P. 11963–11974.
15. Kasprzyk W., et al., Lumenescence phenomena of carbon dots derived from citric acid and urea – a molecular insight. Nanoscale, 2018, 10 (29), P. 13889–13894.
16. Zhou M., et al. Synthesis of highly photoluminescent carbon dots via citric acid and Tris for iron (III) ions sensors and bioimaging. Talanta, 2015, 143, P. 107–113.
17. Zhang Y., et al. One-step microwave synthesis of N-doped hydroxyl-functionalized carbon dots with ultra-high fluorescence quantum yields. Nanoscale, 2016, 8 (33), P. 15281–15287.
18. Zhang Y.Y., et al. A new hydrothermal refluxing route to strong fluorescent carbon dots and its application as fluorescent imaging agent. Talanta, 2013, 117, P. 196–202.
19. Saviz M., et al. Dielectric Spectroscopy of Aqueous TRIS Buffer Solutions at Microwave Frequencies. ICBEM, 2013.
20. Kasprzyk W., et al. The role of molecular fluorophores in the photoluminescence of carbon dots derived from citric acid: current state-of-the-art and future perspectives. Nanoscale, 2022, 14 (39), P. 14368–14384.
21. Ma G., et al. Carbon dots-based fluorescent probe for detection of foodborne pathogens and its potential with microfluidics. Food Chemistry, 2024, 139385.
22. Wang L., et al. Recent research progress of fluorescence biosensors based on carbon dots in early diagnosis of diseases. TrAC Trends in Analytical Chemistry, 2024, 117962.
23. Rasheed P.A., et al. Graphene quantum dots for biosensing and bioimaging. RSC advances, 2024, 14 (23), P. 16001–16023.
24. Wang H., et al. Surface modification functionalized carbon dots. Chemistry – A European J., 2023, 29 (65), e202302383.
Review
For citations:
Nasirov P.D., Novikova S.A., Gribova E.D., Gladyshev P.P., Mukhina I.V. Carbon dots with media-independent fluorescence. Nanosystems: Physics, Chemistry, Mathematics. 2025;16(6):915-918. https://doi.org/10.17586/2220-8054-2025-16-6-915-918
