Аддитивные эффекты зеленого светодиодного света и наночастиц оксида церия на регенерацию планарии

Нанотехнологии позволяют создавать передовые материалы, способные эффективно модулировать радиационное воздействие на клетку в зависимости от интенсивности, длины волны и типа излучения. На сегодняшний день одним из наиболее перспективных биоматериалов, защищающих от ультрафиолетового и рентгеновского излучения, является нанокристаллический оксид церия (CeO₂), обладающий уникальной окислительно-восстановительной активностью благодаря способности восстанавливаться на поверхности. Между тем, модулирующие свойства наночастиц CeO₂ при воздействии на клетки видимого света остаются совершенно неизученными. Проанализировано влияние наночастиц CeO₂ на процесс регенерации планарий после воздействия зеленого светодиодного света низкой интенсивности. Установлено, что однократное воздействие (10 или 25 мин) на регенерирующих планарий зеленым светом низкой интенсивности снижало скорость роста головной бластемы до 20 %. В то же время предварительная обработка планарий наночастицами CeO₂ в наномолярных концентрациях (10-11 М) обеспечивает восстановление активности необластов и значительное ускорение регенерации бластемы. Таким образом, мы впервые показали, что наночастицы оксида церия могут стимулировать процесс регенерации планарии даже при неблагоприятном воздействии низкоинтенсивного излучения зеленого света.

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