Механизм транспорта молекул газа через мембраны эритроцитов кинк-солитонами

Предложена модель возникновения кинков липидной бислойной мембраны эритроцитов, ответственных за транспорт молекул газа, в частности кислорода. Показано, что кинки возникают за счет одновременного действия поперечных и растягивающих продольных механических напряжений, сжимающих мембрану. Эта модель объясняет резкое увеличение проницаемости мембраны для газов при прохождении эритроцита по микрокапиллярной сети с резко возрастающими в ее мембране сжимающими поперечными механическими напряжениями. Установлено, что уравнение движения кинков имеет солитонное решение, поэтому в бислое мембраны эритроцита образуется кинк-солитон. Разработанная модель согласуется с ранее экспериментально установленным фактом, что естественные мембраны эритроцитов в кровотоке претерпевают структурный переход, когда небольшие изменения рН крови, концентрации гормонов и температуры резко изменяют конформацию биомембран и ее функции за счет изменения механического поля напряжений в биомембране.

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