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Conjugation of curcumin with Ag nanoparticle for improving its bioavailability and study of the bioimaging response

https://doi.org/10.17586/2220-8054-2021-12-4-528-535

Abstract

We report here the production of curcumin conjugated polyvinylpyrrolidone (PVP)-capped Ag nanoparticles for potential biological applications.

Evidence for the efficient conjugation of hydrophobic curcumin to the synthesized nanoparticles (NPs) is expected from UV-Vis, zeta potential and Fourier transform infrared (FT-IR) analysis. Curcumin conjugated to PVP-capped Ag NPs is observed to gain high water solubility and bioavailability in a biological environment without diminishing its therapeutic properties. The presence of the main therapeutic group, the diarylheptanoid chromophore of curcumin, indicates the existence of its medicinal behavior in the curcumin-Ag NPs complex. Moreover, the fluorescence efficiency of PVP capped Ag NPs in the breast cancer cellular medium have been found to be significantly enhanced (by factor of ∼2.37) with curcumin conjugation. The production of bioavailable curcumin provides an opportunity to expand the clinical repertoire of this efficacious agent without hampering the environment and human health.

About the Authors

Runjun Sarma
Department of Physics, Mehr Chand Mahajan DAV College for Women
India

Sector 36, Chandigarh.



Monoj Kumar Das
Cancer Genetics and Chemoprevention Research Group, Department of Molecular Biology and Biotechnology, Tezpur University
India

Tezpur, Assam 784028.



Lakshi Saikia
Material Science and Technology Division, CSIR-North East Institute of Science and Technology
India

Jorhat, Assam 785006.



Anand Ramteke
Cancer Genetics and Chemoprevention Research Group, Department of Molecular Biology and Biotechnology, Tezpur University
India

Tezpur, Assam 784028.



Ratul Saikia
Biological Science and Technology Division, CSIR-North East Institute of Science and Technology
India

Jorhat, Assam 785006.



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Review

For citations:


Sarma R., Kumar Das M., Saikia L., Ramteke A., Saikia R. Conjugation of curcumin with Ag nanoparticle for improving its bioavailability and study of the bioimaging response. Nanosystems: Physics, Chemistry, Mathematics. 2021;12(4):528-835. https://doi.org/10.17586/2220-8054-2021-12-4-528-535

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ISSN 2220-8054 (Print)
ISSN 2305-7971 (Online)