Surface plasmon resonance optical sensor for COVID-19 detection
https://doi.org/10.17586/2220-8054-2021-12-5-575-582
Abstract
The transmission of SARS-CoV-2, the novel severe acute respiratory syndrome corona virus have caused the corona virus disease (Covid-19) worldwide pandemic. Overcoming this pandemic requires identifying patients to avoid further spread of the disease. Real-time, sensitive, and costefficient methods for detecting the COVID-19 virus are crucial. Optical sensors provide one such means to achieve this, especially using surface plasmon resonance due to its advantages such as high sensitivity and excellent detection limits. In this paper, we propose a sensor for COVID-19 detection which is based on a simple Kretschmann configuration with gold layers and thiol-tethered DNA for the ligand layer. Angle interrogation was used to obtain the sensitivity of this structure using Matlab numerical analysis. The performance of the sensor was investigated with two types of prisms, SF10 and SF11, while varying the gold layer thickness between 45 – 60 nm. This information was then used to determine which combination of prism and gold thickness are ideal for detecting COVID-19 using thiol-tethered DNA. Thiol-tethered DNA layer sensor showed the highest sensitivity of 137 degree/RIU when a SF10 prism was used with a 50 – 60 nm gold layer and thiol tethered DNA layer.
Supporting agencies: This work was supported by the Airlangga University Research Grant (2021) and the University of Malaya (Grant No: ST036-2020).
About the Authors
H. A. Zain
Photonics Engineering Laboratory, Department of Electrical Engineering, University of Malaya
Malaysia
Malaysia
50603 Kuala Lumpur, Malaysia
M. Batumalay
Faculty of IT, INTI International University
Malaysia
Malaysia
71800 Nilai, Negeri Sembilan
H. R. A. Rahim
Faculty of Electronic and Computer Engineering, Universiti Teknikal Malaysia Melaka
Malaysia
Malaysia
Melaka
Z. Harith
Faculty of Engineering and QS, INTI International University
Malaysia
Malaysia
71800 Nilai, Negeri Sembilan
M. Yasin
Department of Physics, Faculty of Science and Technology, Airlangga University
Indonesia
Indonesia
Surabaya
S. W. Harun
Photonics Engineering Laboratory, Department of Electrical Engineering, University of Malaya
Malaysia
Malaysia
50603 Kuala Lumpur
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Review
For citations:
Zain H.A., Batumalay M., Rahim H.A., Harith Z., Yasin M., Harun S.W. Surface plasmon resonance optical sensor for COVID-19 detection. Nanosystems: Physics, Chemistry, Mathematics. 2021;12(5):575-582. https://doi.org/10.17586/2220-8054-2021-12-5-575-582
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