Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation
https://doi.org/10.17586/2220-8054-2019-10-2-184-189
Abstract
Superparamagnetic iron oxide γ-Fe2O3 (maghemite) nanoparticles (SPION) encapsulated into water-soluble microspheres of rock salt were synthesized via a new aerosol spray pyrolysis procedure. Humic acids (HA) were employed to stabilize the aqueous suspensions of γ-Fe2O3 nanoparticles released upon dissolution of the NaCl matrix. The effect of HA on the surface charge of maghemite-based colloids was studied in pH range of 3 – 10. Humic polyanions compensate positive charges on a hydrated γ-Fe2O3 surface resulting in strongly negative ζ-potential (< −40 mV) of colloid even in acidic environment. In neutral and alkaline environment, ζ-potential of maghemite-based colloid drops below −55 mV; thus, HA should effectively stabilize the nanoparticle colloid over the whole pH range studied. Meanwhile, bare maghemite SPION at pH 3 – 6 have ζ-potential in the +20 mV to −20 mV range (isoelectric point at pH 4.35), which is insufficient for electrostatic stabilization of the suspensions. The absence of embryotoxicity of HA-stabilized nanoparticles was demonstrated.
Keywords
small superparamagnetic iron oxide nanoparticles (SPION),
humic acids,
magnetic fluids,
colloidal properties,
embryotoxicity,
biomedicine
Supporting agencies: The work was carried out within the State Assignment on Fundamental Research to the Kurnakov Institute of General and Inorganic Chemistry.
About the Authors
A. E. Goldt
Skolkovo Institute of Science and Technology
Russian Federation
Russian Federation
Moscow
A. Yu. Polyakov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow 119991
T. A. Sorkina
Science & Technology Department, Management Company RUSNANO, LLC
Russian Federation
Russian Federation
Moscow
A. L. Dubov
Department of Materials Science, Lomonosov Moscow State University ; Department of Chemistry, Lomonosov Moscow State University
Russian Federation
Russian Federation
Moscow 119991
G. A. Davidova
Institute of Theoretical & Experimental Biophysics of Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino 142290
I. I. Selezneva
Institute of Theoretical & Experimental Biophysics of Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino 142290
Y. V. Maximov
Semenov Institute of Chemical Physics of Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow 119991
I. A. Presnyakov
Department of Chemistry, Lomonosov Moscow State University
Russian Federation
Russian Federation
Moscow 119991
N. Yu. Polyakova
I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Moscow
E. A. Goodilin
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences ; Department of Materials Science, Lomonosov Moscow State University ; Department of Chemistry, Lomonosov Moscow State University
Russian Federation
Russian Federation
Moscow 119991
I. V. Perminova
Department of Chemistry, Lomonosov Moscow State University
Russian Federation
Russian Federation
Moscow 119991
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Review
For citations:
Goldt A.E., Polyakov A.Yu., Sorkina T.A., Dubov A.L., Davidova G.A., Selezneva I.I., Maximov Y.V., Presnyakov I.A., Polyakova N.Yu., Goodilin E.A., Perminova I.V. Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation. Nanosystems: Physics, Chemistry, Mathematics. 2019;10(2):184-189. https://doi.org/10.17586/2220-8054-2019-10-2-184-189
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