PVP-stabilized tungsten oxide nanoparticles (WO3) nanoparticles cause hemolysis of human erythrocytes in a dose-dependent manner
https://doi.org/10.17586/2220-8054-2019-10-2-199-205
Abstract
Tungsten oxide nanoparticles (WO3 NPs) are increasingly being considered as a promising material for biomedical applications. However, toxicological information on their effect on red blood cells (RBCs) remains very scarce. In this study, we examined the toxicity of PVPstabilized tungsten oxide nanoparticles against human RBCs. Optical microscopy and spectrophotometry data showed that WO3 NPs induce hemolytic activity. This effect is probably attributed to the direct interaction of the nanoparticles with the RBCs, resulting in the oxidative stress, membrane injury, and subsequent hemolysis.
Supporting agencies: The work supported by Russian Science Foundation (project 18-73-10150).
About the Authors
A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
I. V. Savintseva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
N. R. Popova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
T. O. Shekunova
Lomonosov Moscow State University ; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
O. S. Ivanova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
A. B. Shcherbakov
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine
Ukraine
Ukraine
Kyiv, D0368
D. A. Kozlov
Lomonosov Moscow State University ; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
V. K. Ivanov
Lomonosov Moscow State University ; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
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Review
For citations:
Popov A.L., Savintseva I.V., Popova N.R., Shekunova T.O., Ivanova O.S., Shcherbakov A.B., Kozlov D.A., Ivanov V.K. PVP-stabilized tungsten oxide nanoparticles (WO3) nanoparticles cause hemolysis of human erythrocytes in a dose-dependent manner. Nanosystems: Physics, Chemistry, Mathematics. 2019;10(2):199-205. https://doi.org/10.17586/2220-8054-2019-10-2-199-205
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