Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents
https://doi.org/10.17586/2220-8054-2017-8-2-282-289
Abstract
Modern methods of cancer treatment include chemotherapy and radiotherapy, but they are often characterized by low efficacy and high toxicity. The effectiveness of cancer therapy is often limited by a lack of effective systems for drug delivery to the tumor site. Cerium oxide nanoparticles are able to act as radioprotectors and as radiosensitizers exhibiting selective toxicity in the tumor microenvironment, providing for their tremendous potential in treating cancer. However, methods for controlled delivery of CeO2 nanoparticles to the tumor have not been investigated nor described yet. In this article, we consider different approaches to the development of new ceria nanoparticle-based theranostic agents. Modification of polyelectrolyte microcapsules with nano-ceria appears to be the most promising method. Our design proposals are based on the synergistic pharmacological action of ceria-based nanomaterials and anticancer pharmaceuticals with the ability to control and visualize their sites of localization.
Keywords
Supporting agencies: The reported study was funded by RFBR and the Moscow City Government according to research project No. 15-34-70019 and RFBR project No. 16-34-60248. Ceria-based hybrid materials for cancer theranostics were designed with the support from the Russian Science Foundation (project No. 14-13-01373).
About the Authors
N. R. Popova
Institute of theoretical and experimental biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Institutskaya, 3, Pushchino 142290
A. L. Popov
Institute of theoretical and experimental biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Institutskaya, 3, Pushchino 142290
A. B. Shcherbakov
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine
Ukraine
Ukraine
Str. Zabolotnogo, 154, Kyiv D0368
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences; National Research Tomsk State University
Russian Federation
Russian Federation
Leninsky av, 31, Moscow 119991; Lenin str., 36, Tomsk 634050
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For citations:
Popova N.R., Popov A.L., Shcherbakov A.B., Ivanov V.K. Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents. Nanosystems: Physics, Chemistry, Mathematics. 2017;8(2):282-289. https://doi.org/10.17586/2220-8054-2017-8-2-282-289
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