Toward paclitaxel-[60]fullerene immunoconjugates as a targeted prodrug against cancer
Аннотация
Two newly synthesized water-soluble conjugates of Paclitaxel with malonodiserinolamide-derivatized [60]fullerene (C60-ser) undergo hydrolysis and release their medical payload under biological conditions. In vivo testing of one of these compounds in a murine model showed tumor volume reduction similar to the FDA-approved drug Abraxane, but without the associated weight-loss, indicating better tolerance of this new formulation.
Об авторах
Y. Mackeyev
Rice University
Соединённые Штаты Америки
Соединённые Штаты Америки
M. Raoof
The University of Texas M. D. Anderson Cancer Center
Соединённые Штаты Америки
Соединённые Штаты Америки
B. Cisneros
Rice University; The University of Texas M. D. Anderson Cancer Center
Соединённые Штаты Америки
Соединённые Штаты Америки
N. Koshkina
The University of Texas M. D. Anderson Cancer Center
Соединённые Штаты Америки
Соединённые Штаты Америки
C. Berger
Rice University
Соединённые Штаты Америки
Соединённые Штаты Америки
L. Wilson
Rice University
Соединённые Штаты Америки
Соединённые Штаты Америки
S. Curley
One Baylor Plaza
Соединённые Штаты Америки
Соединённые Штаты Америки
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Рецензия
Для цитирования:
, , , , , , . Наносистемы: физика, химия, математика. 2014;5(1):67-75.
For citation:
Mackeyev Y., Raoof M., Cisneros B., Koshkina N., Berger C.S., Wilson L.J., Curley S.A. Toward paclitaxel-[60]fullerene immunoconjugates as a targeted prodrug against cancer. Nanosystems: Physics, Chemistry, Mathematics. 2014;5(1):67-75.
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