Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells
https://doi.org/10.17586/2220-8054-2018-9-3-430-438
Abstract
A complex analysis of cytotoxicity was performed for a nanodispersed sol of cerium dioxide doped with gadolinium (Ce0.8Gd0.2O2−x) using a culture of mesenchymal stem cells. The absence of cyto- and genotoxicity over a wide range of concentrations (10−5 – 10−9 M) was demonstrated. At that, the highest concentration of Ce0.8Gd0.2O2−x nanoparticles (10−4 M) was found to slightly reduce the activity of intracellular dehydrogenase, yet not leading to the development of apoptosis and further cell death. The obtained results confirm a high degree of Ce0.8Gd0.2O2−x nanoparticle biocompatibility, which opens prospects for their safe application as a contrasting agent in the magnetic resonance tomography.
Supporting agencies: This research has been supported by the Russian Science Foundation (project 17-73-10417).
About the Authors
A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
I. V. Savintseva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
E. A. Mysina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
A. B. Shcherbakov
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine
Ukraine
Ukraine
Kyiv D0368
N. R. Popova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
O. S. Ivanova
Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow 119991
D. D. Kolmanovich
Kabardino-Balkarian State University
Russian Federation
Russian Federation
Nalchik, 360004
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences; Moscow Technological University, Institute of Fine Chemical Technologies
Russian Federation
Russian Federation
Moscow 119991
Moscow 119991
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Review
For citations:
Popov A.L., Savintseva I.V., Mysina E.A., Shcherbakov A.B., Popova N.R., Ivanova O.S., Kolmanovich D.D., Ivanov V.K. Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells. Nanosystems: Physics, Chemistry, Mathematics. 2018;9(3):430-438. https://doi.org/10.17586/2220-8054-2018-9-3-430-438
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