Magnet-induced behavior of iron carbide (Fe7C3@C) nanoparticles in the cytoplasm of living cells
https://doi.org/10.17586/2220-8054-2016-7-1-158-160
Abstract
The uptake of superparamagnetic Fe7C3@C nanoparticles into living cells and their behavior once inside the cell was investigated. The cells used were shown to absorb the nanoparticle aggregates over the first 30 minutes. After absorption, these aggregates moved towards the center of the cell and accumulated near the cell nucleus. No toxic effects on cell physiology were observed. In a magnetic field, the particles aligned in the cells along magnetic lines and shifted to the magnet’s side. During long-term cultivation, Fe7C3@C nanoparticle aggregates were ultimately discarded via exocytosis.
Supporting agencies: This work was supported by Russian Foundation for Basic Research (Grants 12-03- 00787, 12-04-00488, 13-04-00885, 15-03-04490) and Moscow State University Development Program PNR 5.13. Our data were obtained with the assistance of the RIO Electron Microscopy Facility of François Rabelais University and CHRU de Tours.
About the Authors
I. Alieva
Belozersky Institute of Physico-Chemical Biology, Moscow State University
Russian Federation
Russian Federation
Moscow
I. Kireev
Belozersky Institute of Physico-Chemical Biology, Moscow State University
Russian Federation
Russian Federation
Moscow
A. Rakhmanina
L.F. Vereshchagin Institute for High Pressure Physics of the RAS
Russian Federation
Russian Federation
Troitsk
A. Garanina
Belozersky Institute of Physico-Chemical Biology, Moscow State University
Russian Federation
Russian Federation
Moscow
O. Strelkova
Belozersky Institute of Physico-Chemical Biology, Moscow State University
Russian Federation
Russian Federation
Moscow
O. Zhironkina
Belozersky Institute of Physico-Chemical Biology, Moscow State University
Russian Federation
Russian Federation
Moscow
V. Cherepaninets
Belozersky Institute of Physico-Chemical Biology, Moscow State University
Russian Federation
Russian Federation
Moscow
V. Davydov
L.F. Vereshchagin Institute for High Pressure Physics of the RAS
Russian Federation
Russian Federation
Troitsk
V. Khabashesku
Center for Technology Innovation, Baker Hughes Inc.
United States
United States
Houston, TX, 77040
V. Agafonov
GREMAN, UMR CNRS 7347, Université François Rabelais
France
France
37200 Tours
R. Uzbekov
Faculté de Médecine, Université François Rabelais; Faculty of Bioengineering and Bioinformatics, Moscow State University
Russian Federation
Russian Federation
Tours; Moscow
References
1. Davydov V., Rakhmanina A., Kireev I., Alieva I., Zhironkina O., Strelkova O., Dianova V., Samani T.D., Mireles M., Hocine Yahia L., Uzbekov R., Agafonov V., Khabashesku V. Solid state synthesis of carbon-encapsulated iron carbide nanoparticles and their interaction with living cells. J. Mater. Chem. B, 2014, 2, P. 4250–4261.
2. Uzbekov R.E., Kireev I.I., Alieva I.B., Davydov V. A., Rakhmanina A.V., Agafonov V. Interaction of Iron Carbide Nanoparticles protected by Carbon Shell Onion-like Structure with living Cells. Joint Intern. Conf. “Advanced Carbon Nanostructures” (ACNS’ 2013) St. Petersburg, Russia.
Review
For citations:
Alieva I., Kireev I., Rakhmanina A., Garanina A., Strelkova O., Zhironkina O., Cherepaninets V., Davydov V., Khabashesku V., Agafonov V., Uzbekov R. Magnet-induced behavior of iron carbide (Fe7C3@C) nanoparticles in the cytoplasm of living cells. Nanosystems: Physics, Chemistry, Mathematics. 2016;7(1):158-160. https://doi.org/10.17586/2220-8054-2016-7-1-158-160
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