Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application
https://doi.org/10.17586/2220-8054-2021-12-3-329-335
Аннотация
This paper is aimed at the experimental study (in animal models) of acute toxicity and irritating properties of polysaccharide hydrogel modified with cerium oxide nanoparticles. In the acute experiment, there were no indications of irritating action of the gel at the site of application when the hydrogel was administered intragastrically or epicutaneously. No lethal effects were registered during this experiment even at the highest concentration. The results obtained demonstrate the lack of acute toxicity and local irritability of the synthesized hybrid hydrogel, which allows to classify the developed hybrid hydrogel as the relatively low-risk drug.
Об авторах
A. Popov
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences; Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Россия
Россия
V. Andreeva
Moscow Regional Research and Clinical Institute, Laboratory of Medical and Physics Research
Россия
Россия
N. Khohlov
I. M. Sechenov First Moscow State Medical University
Россия
Россия
K. Kamenskikh
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
V. Gavrilyuk
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
V. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Россия
Россия
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Рецензия
Для цитирования:
, , , , , . Наносистемы: физика, химия, математика. 2021;12(3):329-335. https://doi.org/10.17586/2220-8054-2021-12-3-329-335
For citation:
Popov A.L., Andreeva V.V., Khohlov N.V., Kamenskikh K.A., Gavrilyuk V.B., Ivanov V.K. Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application. Nanosystems: Physics, Chemistry, Mathematics. 2021;12(3):329-335. https://doi.org/10.17586/2220-8054-2021-12-3-329-335
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