Комплексный анализ цитотоксичности полисахаридного гидрогеля, модифицированного наночастицами оксида церия, для применения в заживлении ран
https://doi.org/10.17586/2220-8054-2021-12-3-329-335
Аннотация
Целью данной работы является экспериментальное изучение (на животных моделях) острой токсичности и раздражающих свойств полисахаридного гидрогеля, модифицированного наночастицами оксида церия. В остром эксперименте не было признаков раздражающего действия геля в месте аппликации при внутрижелудочном или накожном введении гидрогеля. Летальных эффектов в этом эксперименте не зарегистрировано даже при самой высокой концентрации. Полученные результаты демонстрируют отсутствие у синтезированного гибридного гидрогеля острой токсичности и местного раздражающего действия, что позволяет отнести разработанный гибридный гидрогель к препаратам относительно низкого риска.
Ключевые слова
заживление ран,
гидрогель,
наночастицы оксида церия,
накожное применение,
регенерация,
пролиферация клеток
Об авторах
A. L. Popov
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences; Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Россия
Россия
V. V. Andreeva
Moscow Regional Research and Clinical Institute, Laboratory of Medical and Physics Research
Россия
Россия
N. V. Khohlov
I. M. Sechenov First Moscow State Medical University
Россия
Россия
K. A. Kamenskikh
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
V. B. Gavrilyuk
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Россия
Россия
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
Россия
Россия
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Рецензия
Для цитирования:
Popov A.L., Andreeva V.V., Khohlov N.V., Kamenskikh K.A., Gavrilyuk V.B., Ivanov V.K. Комплексный анализ цитотоксичности полисахаридного гидрогеля, модифицированного наночастицами оксида церия, для применения в заживлении ран. Наносистемы: физика, химия, математика. 2021;12(3):329-335. https://doi.org/10.17586/2220-8054-2021-12-3-329-335
For citation:
Popov A.L., Andreeva V.V., Khohlov N.V., Kamenskikh K.A., Gavrilyuk V.B., Ivanov V.K. Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application. Nanosystems: Physics, Chemistry, Mathematics. 2021;12(3):329-335. https://doi.org/10.17586/2220-8054-2021-12-3-329-335
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