PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts via induction of intracellular oxidative stress
https://doi.org/10.17586/2220-8054-2019-10-1-92-101
Abstract
In this study, photochromic PVP-stabilized tungsten oxide nanoparticles (WO3-x NPs) were shown to exhibit a dose-dependent cytotoxic effect on mouse fibroblasts in vitro. WO3-x NPs reduce viability and proliferative activity of the cells via induction of intracellular oxidative stress leading to apoptosis and cell death. WO3-x NPs modulate the mRNA expression of a wide range of genes responsible for oxidative stress and the cell redox-system.
Supporting agencies: This study was funded by Russian Science Foundation (project 18-73-10150).
About the Authors
A. L. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
A. M. Ermakov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
T. O. Shekunova
Lomonosov Moscow State University ; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
A. B. Shcherbakov
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine
Ukraine
Ukraine
Kyiv, D0368
O. N. Ermakova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
O. S. Ivanova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
N. R. Popova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Russian Federation
Russian Federation
Pushchino, Moscow region, 142290
A. Ye. Baranchikov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
V. K. Ivanov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Russian Federation
Russian Federation
Moscow, 119991
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Review
For citations:
Popov A.L., Ermakov A.M., Shekunova T.O., Shcherbakov A.B., Ermakova O.N., Ivanova O.S., Popova N.R., Baranchikov A.Ye., Ivanov V.K. PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts via induction of intracellular oxidative stress. Nanosystems: Physics, Chemistry, Mathematics. 2019;10(1):92-101. https://doi.org/10.17586/2220-8054-2019-10-1-92-101
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