PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts via induction of intracellular oxidative stress
https://doi.org/10.17586/2220-8054-2019-10-1-92-101
Аннотация
In this study, photochromic PVP-stabilized tungsten oxide nanoparticles (WO3-x NPs) were shown to exhibit a dose-dependent cytotoxic effect on mouse fibroblasts in vitro. WO3-x NPs reduce viability and proliferative activity of the cells via induction of intracellular oxidative stress leading to apoptosis and cell death. WO3-x NPs modulate the mRNA expression of a wide range of genes responsible for oxidative stress and the cell redox-system.
Об авторах
A. Popov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Россия
Россия
A. Ermakov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Россия
Россия
T. Shekunova
Lomonosov Moscow State University ; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Россия
Россия
A. Shcherbakov
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine
Украина
Украина
O. Ermakova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Россия
Россия
O. Ivanova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Россия
Россия
N. Popova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Россия
Россия
A. Baranchikov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Россия
Россия
V. Ivanov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Россия
Россия
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Рецензия
Для цитирования:
, , , , , , , , . Наносистемы: физика, химия, математика. 2019;10(1):92-101. https://doi.org/10.17586/2220-8054-2019-10-1-92-101
For citation:
Popov A.L., Ermakov A.M., Shekunova T.O., Shcherbakov A.B., Ermakova O.N., Ivanova O.S., Popova N.R., Baranchikov A.Ye., Ivanov V.K. PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts via induction of intracellular oxidative stress. Nanosystems: Physics, Chemistry, Mathematics. 2019;10(1):92-101. https://doi.org/10.17586/2220-8054-2019-10-1-92-101
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