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NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2019, 10 (1), P. 92–101

PVP-stabilized tungsten oxide nanoparticles inhibit proliferation of NCTC L929 mouse fibroblasts via induction of intracellular oxidative stress

A. L. Popov – Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; antonpopovleonid@gmail.com
A. M. Ermakov – Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; ao_ermakovy@rambler.ru
T. O. Shekunova – Lomonosov Moscow State University, Moscow, 119991; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; taisia.shekunova@yandex.ru
A. B. Shcherbakov – Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, D0368, Ukraine; carotene@igic.ras.ru
O. N. Ermakova – Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; beoluchi@yandex.ru
O. S. Ivanova – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; runetta05@mail.ru
N. R. Popova – Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; nellipopovaran@gmail.com
A.Ye. Baranchikov – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; a.baranchikov@yandex.ru
V. K. Ivanov – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; van@igic.ras.ru

In this study, photochromic PVP-stabilized tungsten oxide nanoparticles (WO3-x NPs) were shown to exhibit a dose-dependent cytotoxic effect on mouse fibroblasts in vitro. WO3-x NPs reduce viability and proliferative activity of the cells via induction of intracellular oxidative stress leading to apoptosis and cell death. WO3-x NPs modulate the mRNA expression of a wide range of genes responsible for oxidative stress and the cell redox-system.

Keywords: tungsten oxide nanoparticles, cytotoxicity, apoptosis, fibroblasts.

PACS 68.65.k, 81.20.n, 82.70.Dd, 82.50.Hp, 87.17.Ee

DOI 10.17586/2220-8054-2019-10-1-92-101

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