NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2019, 10 (2), P. 199–205
PVP-stabilized tungsten oxide nanoparticles (WO3) nanoparticles cause hemolysis of human erythrocytes in a dose-dependent manner
A. L. Popov – Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; antonpopovleonid@gmail.com
I.V. Savintseva – Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; savintseva_irina@mail.ru
N. R. Popova – Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; nellipopovaran@gmail.com
T. O. Shekunova – Lomonosov Moscow State University, Moscow, 119991; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; taisia.shekunova@yandex.ru
O. S. Ivanova – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; runetta05@mail.ru
A. B. Shcherbakov – Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, D0368, Ukraine; carotene@igic.ras.ru
D. A. Kozlov – Lomonosov Moscow State University, Moscow, 119991; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; kozlov@inorg.chem.msu.ru
V. K. Ivanov – Lomonosov Moscow State University, Moscow, 119991; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia; van@igic.ras.ru
Tungsten oxide nanoparticles (WO3 NPs) are increasingly being considered as a promising material for biomedical applications. However, toxicological information on their effect on red blood cells (RBCs) remains very scarce. In this study, we examined the toxicity of PVP-stabilized tungsten oxide nanoparticles against human RBCs. Optical microscopy and spectrophotometry data showed that WO3 NPs induce hemolytic activity. This effect is probably attributed to the direct interaction of the nanoparticles with the RBCs, resulting in the oxidative stress, membrane injury, and subsequent hemolysis.
Keywords: tungsten oxide nanoparticles, human erythrocytes, hemolysis.
PACS 68.65.k, 81.20.n, 82.70.Dd, 87.17.Ee
DOI 10.17586/2220-8054-2019-10-2-199-205
