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NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2021, 12 (1), P. 81–112

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

A. A. Ostroushko – Ural Federal University named after the first President of Russia B. N. Yeltsin, Ekaterinburg, Russia; alexander.ostroushko@urfu.ru
K.V. Grzhegorzhevskii – Ural Federal University named after the first President of Russia B. N. Yeltsin, Ekaterinburg, Russia
S.Yu. Medvedeva – Ural Federal University named after the first President of Russia B. N. Yeltsin, Ekaterinburg; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia
I. F. Gette – Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia
M. O. Tonkushina – Ural Federal University named after the first President of Russia B. N. Yeltsin, Ekaterinburg, Russia
I. D. Gagarin – Ural Federal University named after the first President of Russia B. N. Yeltsin, Ekaterinburg, Russia
I. G. Danilova – Ural Federal University named after the first President of Russia B. N. Yeltsin, Ekaterinburg; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia

The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

Keywords: Keplerate-type nanocluster polyoxomolybdates, physicochemical and biochemical properties, impact on living systems, means of targeted delivery, releasing systems, prolonged action.

DOI 10.17586/2220-8054-2021-12-1-81-112

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