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NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2021, 12 (2), P. 175–181

Additive effects of green LED light and cerium oxide nanoparticles on the planarian’s regeneration

A. M. Ermakov – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia; ao_ermakovy@rambler.ru
K. A. Kamenskikh – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia; kristina.kamensk@mail.ru
A. L. Popov – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia; antonpopovleonid@gmail.com
O. N. Ermakova – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia; beoluchi@yandex.ru
V. A. Afanasyeva – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia; va_vera_afanaseva@mail.ru
V. K. Ivanov – Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Leninskiy prosp., 31, Moscow, 119991, Russia; van@igic.ras.ru

Nanotechnology makes it possible to design advanced materials being able to effectively modulate radiation effects on a cell, depending on the
radiation intensity, wavelength, and type. Today, one of the most promising UV and X-ray protective biomaterials is nanocrystalline cerium oxide (CeO2), which has a unique redox activity due to its surface reducibility. Meanwhile, the modulating properties of CeO2 nanoparticles when the cells are exposed to visible light remain completely unexplored. Here, we analyzed the impact of CeO2 nanoparticles on the process of planarian regeneration after exposure to low-intensity green LED light. It was found that a one-time exposure (10 or 25 min) of regenerating planarians with low-intensity green light reduced head blastema growth rate by up to 20%. At the same time, the preliminary treatment of planaria with CeO2 nanoparticles in nanomolar concentrations (10-11 M) ensures the restoration of the neoblasts activity and a significant acceleration of blastema regeneration. Thus, we have firstly demonstrated that the planarian regeneration process can be promoted by cerium oxide nanoparticles even under adverse action of low-intensity green light radiation.

Keywords: cerium oxide nanoparticles, green LED, planarian regeneration.

PACS 61.46.+w, 87.50.-a, 87.19.-j

DOI 10.17586/2220-8054-2021-12-2-175-181

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