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NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2021, 12 (3), P. 329–335

Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application

A. L. Popov – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290; Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Leninskiy prosp., 31, Moscow, 119991, Russia; antonpopovleonid@gmail.com
V. V. Andreeva – Moscow Regional Research and Clinical Institute, Laboratory of Medical and Physics Research, Shchepkina str. 61/2, Moscow, 129110, Russia; viktoriaa@yandex.ru
N. V. Khohlov – I. M. Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya str., 19s1, Moscow, 119146, Russia; nikolay.khokhlov@gmail.com
K. A. Kamenskikh – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia; kristina.kamensk@mail.ru
V. B. Gavrilyuk – Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya str., 3, Pushchino, 142290, Russia; vbg@mail.ru
V. K. Ivanov – Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Leninskiy prosp., 31, Moscow, 119991, Russia; van@igic.ras.ru

This paper is aimed at the experimental study (in animal models) of acute toxicity and irritating properties of polysaccharide hydrogel modified with cerium oxide nanoparticles. In the acute experiment, there were no indications of irritating action of the gel at the site of application when the hydrogel was administered intragastrically or epicutaneously. No lethal effects were registered during this experiment even at the highest concentration. The results obtained demonstrate the lack of acute toxicity and local irritability of the synthesized hybrid hydrogel, which allows to classify the developed hybrid hydrogel as the relatively low-risk drug.

Keywords: wound healing, hydrogel, cerium oxide nanoparticles, epicutaneous application, regeneration, cell proliferation.

PACS 68.65.-k, 81.20.-n, 82.70.Dd, 87.80.-y

DOI 10.17586/2220-8054-2021-12-3-329-335

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