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NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2021, 12 (4), P. 528–535

Conjugation of curcumin with Ag nanoparticle for improving its bioavailability and study of the bioimaging response

Runjun Sarma – Department of Physics, Mehr Chand Mahajan DAV College for Women, Sector 36, Chandigarh, India; runjun2018chd@gmail.com
Monoj Kumar Das – Cancer Genetics and Chemoprevention Research Group, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam 784028, India
Lakshi Saikia – Material Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam 785006, India
Anand Ramteke – Cancer Genetics and Chemoprevention Research Group, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam 784028, India
Ratul Saikia – Biological Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam 785006, India

We report here the production of curcumin conjugated polyvinylpyrrolidone (PVP)-capped Ag nanoparticles for potential biological applications.
Evidence for the efficient conjugation of hydrophobic curcumin to the synthesized nanoparticles (NPs) is expected from UV-Vis, zeta potential and Fourier transform infrared (FT-IR) analysis. Curcumin conjugated to PVP-capped Ag NPs is observed to gain high water solubility and bioavailability in a biological environment without diminishing its therapeutic properties. The presence of the main therapeutic group, the diarylheptanoid chromophore of curcumin, indicates the existence of its medicinal behavior in the curcumin-Ag NPs complex. Moreover, the fluorescence efficiency of PVP-capped Ag NPs in the breast cancer cellular medium have been found to be significantly enhanced (by factor of ~2.37) with curcumin conjugation. The production of bioavailable curcumin provides an opportunity to expand the clinical repertoire of this efficacious agent without hampering the environment and human health.

Keywords: therapeutic, bioavailability, imaging, curcumin, PVP.

DOI 10.17586/2220-8054-2021-12-4-528-535

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