NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2019, 10 (2), P. 184–189
Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation
A. E. Goldt – Skolkovo Institute of Science and Technology, Moscow, Russia
A.Yu. Polyakov – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia; a.yu.polyakov@gmail.com
T. A. Sorkina – Science & Technology Department, Management Company RUSNANO, LLC, Moscow, Russia
A. L. Dubov – Department of Materials Science, Lomonosov Moscow State University, Moscow 119991; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia
G. A. Davidova – Institute of Theoretical & Experimental Biophysics of Russian Academy of Sciences, Pushchino 142290, Russia
I. I. Selezneva – Institute of Theoretical & Experimental Biophysics of Russian Academy of Sciences, Pushchino 142290, Russia
Y.V. Maximov – Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow 119991, Russia
I. A. Presnyakov – Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia
N.Yu. Polyakova – I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia
E. A. Goodilin – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991; Department of Materials Science, Lomonosov Moscow State University, Moscow 119991; Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia
I.V. Perminova – Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia
Superparamagnetic iron oxide γ-Fe2O3 (maghemite) nanoparticles (SPION) encapsulated into water-soluble microspheres of rock salt were synthesized via a new aerosol spray pyrolysis procedure. Humic acids (HA) were employed to stabilize the aqueous suspensions of γ-Fe2O3 nanoparticles released upon dissolution of the NaCl matrix. The effect of HA on the surface charge of maghemite-based colloids was studied in pH range of 3 – 10. Humic polyanions compensate positive charges on a hydrated γ-Fe2O3 surface resulting in strongly negative ζ-potential (< -40 mV) of colloid even in acidic environment. In neutral and alkaline environment, ζ-potential of maghemite-based colloid drops below -55 mV; thus, HA should effectively stabilize the nanoparticle colloid over the whole pH range studied. Meanwhile, bare maghemite SPION at pH 3 – 6 have ζ-potential in the +20 mV to -20 mV range (isoelectric point at pH 4.35), which is insufficient for electrostatic stabilization of the suspensions. The absence of embryotoxicity of HA-stabilized nanoparticles was demonstrated.
Keywords: small superparamagnetic iron oxide nanoparticles (SPION), humic acids, magnetic fluids, colloidal properties, embryotoxicity, biomedicine.
PACS 75.47.Lx, 82.70.Dd
DOI 10.17586/2220-8054-2019-10-2-184-189
