NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2019, 10 (3), P. 289–302
Synergetic action of ceria nanoparticles and doxorubicin on the early development of two fish species, Danio rerio and Puntius tetrazona
E.Yu. Krysanov – Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071 Russia; krysanov@sevin.ru
T. B. Demidova – Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071 Russia
O. S. Ivanova – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991; National Research Tomsk State University, Tomsk, 634050 Russia
K. G. Ordzhonikidze – Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991 Russia
A. B. Shcherbakov – Zabolotny Institute of Microbiology and Virology,NAS of Ukraine, Kiev, D 03680 Ukraine
V. K. Ivanov – Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russia; van@igic.ras.ru
The combined action of ceria nanoparticles and doxorubicin on the early stages of ontogenesis of Danio rerio and Puntius tetrazona was studied. Results obtained indicate that there is a synergetic effect of CeO2 nanoparticles and doxorubicin which is demonstrated by a high incidence of embryonic malformations in fish. This synergetic effect is more pronounced in tiger barbs than in zebrafish, and depends strongly on the synthetic route of ceria nanoparticles’ preparation, the most notable effects being registered for citrate-stabilized nanoparticles.
Keywords: cerium dioxide, nanotoxicology, zebrafish, doxorubicin, embryotoxicity.
PACS 87.18.h, 89.60.k
DOI 10.17586/2220-8054-2019-10-3-289-302
