NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2017, 8 (2), P. 282–289
Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents
N. R. Popova – Institute of theoretical and experimental biophysics of the Russian Academy of Sciences, Institutskaya, 3, Pushchino 142290, Russia; nellipopovaran@gmail.com
A. L. Popov – Institute of theoretical and experimental biophysics of the Russian Academy of Sciences, Institutskaya, 3, Pushchino 142290, Russia; antonpopovleonid@gmail.com
A. B. Shcherbakov – Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Str. Zabolotnogo, 154, Kyiv D0368, Ukraine; carotene@igic.ras.ru
V. K. Ivanov – Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Leninsky av, 31, Moscow 119991; 4National Research Tomsk State University, Lenin str., 36, Tomsk 634050, Russia; van@igic.ras.ru
Modern methods of cancer treatment include chemotherapy and radiotherapy, but they are often characterized by low efficacy and high toxicity. The effectiveness of cancer therapy is often limited by a lack of effective systems for drug delivery to the tumor site. Cerium oxide nanoparticles are able to act as radioprotectors and as radiosensitizers exhibiting selective toxicity in the tumor microenvironment, providing for their tremendous potential in treating cancer. However, methods for controlled delivery of CeO2 nanoparticles to the tumor have not been investigated nor described yet. In this article, we consider different approaches to the development of new ceria nanoparticle-based theranostic agents. Modification of polyelectrolyte microcapsules with nano-ceria appears to be the most promising method. Our design proposals are based on the synergistic pharmacological action of ceria-based nanomaterials and anticancer pharmaceuticals with the ability to control and visualize their sites of localization.
Keywords: cerium oxide nanoparticles, polyelectrolyte microcapsules, theranostics agents, radiation therapy.
PACS 68.65.-k, 81.07.Pr, 81.16.Be, 87.85.Qr
DOI 10.17586/2220-8054-2017-8-2-282-289