NANOSYSTEMS: PHYSICS, CHEMISTRY, MATHEMATICS, 2017, 8 (3), P. 391–396
Biological effect of zirconium dioxide-based nanoparticles
O.V. Almjasheva – St. Petersburg Electrotechnical University “LETI”, ul. Professora Popova 5, 197376 St. Petersburg; Ioffe Institute, Politekhnicheskaya st., 26, St. Petersburg, 194021, Russia; almjasheva@mail.ru
A.V. Garabadzhiu – St. Petersburg State Technological Institute (Technical university) Moskovsky prospect 26, 190013 St. Petersburg, Russia
Yu.V. Kozina – St. Petersburg State Technological Institute (Technical university) Moskovsky prospect 26, 190013 St. Petersburg, Russia
L. F. Litvinchuk – State Research Institute of Highly Pure Biopreparations of the Federal Medical Biological Agency FMB, Pudozhskaya ul. 7, 197110 St. Petersburg, Russia
V. P. Dobritsa – State Research Institute of Highly Pure Biopreparations of the Federal Medical Biological Agency FMB, Pudozhskaya ul. 7, 197110 St. Petersburg, Russia
This work demonstrates the positive effects of zirconium dioxide nanoparticles on cells in vitro. This is supported by the absence of toxicity, stimulation of metabolic and proliferative activity. The nanoparticles of solid solution of europium oxide in europium dioxide do not exhibit an explicit biological effect. The potentially successful application of zirconium dioxide-based nanoparticles in pharmacology has been demonstrated.
Keywords: zirconium dioxide, europium oxide, nanoparticles, toxicity, metabolic activity, proliferative activity.
PACS 61.46.+w, 42.62
DOI 10.17586/2220-8054-2017-8-3-391-396